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EC number: 203-466-5
CAS number: 107-13-1
The analyses of the chamber atmospheres indicated that
the mean analytical values of acrylonitrile ± SD for the 5, 15, 45 and
90 ppm groups were; 5.0±0.30, 15.1±0.69, 45.3±1.51, and 89.4±3.58 ppm,
respectively. No test chemical was detected in the control atmospheres.
A two-generation reproductive toxicity study was conducted in
Sprague-Dawley rats; the data presented here relate to the repeated dose
inhalation toxicity effects on the parental animals (F0 generation).
Twenty-five rats/sex/group were exposed to vapour atmospheres of
acrylonitrile via whole-body inhalation at concentrations of 0, 5, 15,
45 and 90 ppm, 6 hours daily, on 7 days a week for 10 weeks. Males were
exposed for 10 weeks prior to mating and throughout mating until 1 day
prior to termination. Females were exposed for 10 weeks prior to mating
and throughout mating, gestation, and lactation until 1 day prior to
termination. Exposure of the dams was suspended for 5 days following
parturition (lactation days 0 -4) to avoid confounding nesting and
nursing behaviour and neonatal survival. Exposure of the dams resumed on
Day 5; rats were removed from the litters for 6 hours exposure at about
the same time each day. There were no exposure-related mortalities.
Bodyweight gain was significantly reduced at 45 and 90 ppm. Food
consumption was also reduced at these dose levels, but the difference
was only significant at 90 ppm. Clinical signs indicative of the
irritant properties of acrylonitrile were observed in rats exposed to 90
ppm throughout the exposure period and within 1 hour of cessation of
exposure; the irritant effects of the test material did not generally
persist to the following day. Acrylonitrile-related microscopic
alterations were limited to morphologically similar nasal lesions in the
F0 males and females at 45 ppm, F1 males at 5, 15, and 45 ppm, and the
F1 females at 15 and 45 ppm. Four levels of the nasal cavity were
examined microscopically for the 5, 15, and 45 ppm groups. Lesions
showed a clear exposure-response relationship in incidence and included
respiratory/transitional epithelial hyperplasia, sub-acute inflammation,
squamous metaplasia, and/or degeneration of the olfactory
epithelium. The majority of the lesions were present in the most rostral
section (level I) of the nasal tissues examined and are consistent with
site-of-contact irritation resulting from exposure to irritant chemicals
as reported in the literature by a number of authors. All of the nasal
lesions noted in this study are common findings in the nasal epithelium
of the rat following sub-chronic to chronic inhalation exposure with an
irritating compound and represent the effects of local irritation,
rather than a systemic effect. No other treatment-related
histopathological findings were noted at any exposure level. Based on
the incidence of local irritant effects in the nasal cavity at all
exposure levels, a NOAEC cannot be determined for this study. A LOAEC of
5 ppm is determined.
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