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EC number: 203-466-5
CAS number: 107-13-1
No signs of systemic toxicity were noted during the primary irritation
experiments and during the main study. No mortality occurred/ Average
body weight gain was similar in treated guinea pigs and controls.
Four animals showed skin irritation after the 48 hours occluded
epicutaneous induction exposure. No positive skin reactions were
observed in the controls following the challenge exposure.
Nineteen animals showed a positive sensitisation reaction in response to
the 1% and 0.5% test concentrations, and 16 animals in response to the
0.2% concentration. Two animals showed a skin reaction to the vehicle
alone. It was therefore concluded that leakage of the test material
across the Square chambers had cocurred. Another minor reaction to the
test material was scaliness.
The resulting sensitisation rate was 95%, indicating that acrylonitrile
is an extreme sensitiser according to the Kligman (1966) rating.
Positive skin reactions scored after challenge exposure
Experimental group – no. animals with positive reaction
Control group – no. animals with positive reaction
* it was considered possible that some test material
leaked from the other chambers
The sensitising properties of acrylonitrile were evaluated in the Guinea
Pig Maximisation Test. Under the conditions of the study, acrylonitrile
resulted in a 95% sensitisation rate after intracutaneous and
epicutaneous application. Acrylonitrile should therefore be classified
as a skin sensitiser in Category 1B according to Regulation (EC)
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