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EC number: 203-466-5
CAS number: 107-13-1
An anonymous author (Japan MoE, 2011) reports a 72-hour ErC50 of 10 mg/L
(mean measured) for the inhibitory effects of acrylonitrile on the
growth rate of the freshwater unicellular alga Pseudokirchneriella
subcapitata. This study was performed on behalf of the Japanese
Ministry of the Environment in accordance with a Japanese national
method and OECD TG 201, and in compliance with GLP. The test was
conducted under static conditions in OECD algal growth medium with
sealed test vessels to limit volatilisation losses of the test substance
and maintain exposure concentrations.
The effects of acrylonitrile on the growth of P. subcapitata were
reliably determined following exposure for 72 hours under static
conditions in sealed vessels. Measured concentrations at test
initiation (0 h) ranged between 91% and 99% of nominals and residual
concentrations recovered at termination (72 h) were between 90% and 100%
of nominals, demonstrating that exposure had been satisfactorily
maintained during the incubation. All the guideline validity criteria
were met. The 72-hour ErC50 was 10 mg/L and the corresponding NOErC was
0.95 mg/L. Since the NOErC relates to algal growth (cell
multiplication), it is considered to be a long-term endpoint for the
primary producer trophic group and is taken into account in setting the
assessment factor for the derivation of the aquatic PNEC.
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