Registration Dossier

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
bioaccumulation in aquatic species: fish
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance has a low potential for bioaccumulation based on log Kow <=3
Reason / purpose:
data waiving: supporting information

Description of key information

No data are available: a waiver is proposed for this endpoint. Bioaccumulation of acrylonitrile is not anticipated, given experimentally-derived values of 0-0.3 for the log Kow, and a bioconcentration factor (BCF) of 1.0 has been calculated from the known water solubility of acrylonitrile.

Key value for chemical safety assessment

BCF (aquatic species):
1 dimensionless

Additional information

Physicochemical considerations and experimental evidence suggest that acrylonitrile is unlikely to bioaccumulate in exposed biota, and toxicity studies in mammalian species provide little evidence of cumulative toxicity in a range of species. Concentrations of acrylonitrile in biota are expected to be very low, and it is therefore concluded that the potential for secondary poisoning is very small.

Bioaccumulation of acrylonitrile is not anticipated, given experimentally-derived values of 0-0.3 for the log Kow, and a bioconcentration factor (BCF) of 1.0 has been calculated from the known water solubility of acrylonitrile.