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EC number: 202-448-4
CAS number: 95-76-1
In general, 3,4 -dichloroaniline was well tolerated and there were no
overt adverse clinical signs of toxicity. However, body weight gains and
food consumption were significantly reduced during treatment for both
the 25 and 125 mg/kg groups. Dose levels of 5 and 25 mg/kg produced no
statistically significant or toxicologically relevant adverse effects on
any maternal reproductive or fetal parameter studied. There was no
evidence of embryotoxicity (increased resorption), fetotoxicity (reduced
growth/ delayed ossification), nor any increase in either the fetal or
litter incidence of malformations for these groups. Although not
statistically significant, there was a slight increase in resorption and
consequently, post-implantation loss for the 125 mg/kg group which is
considered treatment-related. The high-dose also promoted delayed
ossification of several skeletal elements.
Clemens and Hartnagel, 1990
In the teratogenicity study 3,4 -Dichloroaniline, administered to gravid
rats at doses up to and including 25 mg/kg, is devoid of any toxicity,
and/ or teratogenicity. Because of significantly reduced body weight
gains and food consumption at dose levels of 25 and 125 mg/ kg a dose of
5 mg/kg is considered the maternal NOEL. As a result of a significant
increase in delayed ossification of a few skeletal elements and an
increase in the incidence of resorption and post-implantation loss at
125 mg/kg, a dose of 25 mg/kg is considered the NOEL for developmental
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