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EC number: 202-448-4
CAS number: 95-76-1
no further data
Herbold, B, Bayer-report no. 13085, 1984
3,4 -DCA was tested for mutagenicity in Salmonella typhimurium ( TA98,
TA100, TA 1535 and TA 1537) similar to OECD 471 and EU methods B.13/14
(without testing of A/T base pair revertant strains). The tests were
conducted according to the method of Ames et al. (1975). After 48 h of
incubation growth of revertant colonies on histidine deficient selection
agar was counted and compared to vehicle controls. 3,4 dichloroaniline
did not produces a reproducible, dose related response over the solvent
control, under a single metabolic activation condition, in replicate
trials. The obtained results therefore indicate that 3,4 -DCA in a
concentration of up to 500 µg/ plate appeared to be nonmutagenic in
these Salmonella strains. Higher doses were cytotoxic, as indicated by
reduced His+ revertant colonies.
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