Registration Dossier
Registration Dossier
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EC number: 202-448-4 | CAS number: 95-76-1
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable, well documented publication, which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Development and evaluation of an HPLC urinalysis screening test of occupational exposure to 3,4- and 3,5-dichloroanilines
- Author:
- El Marbough, L. et al.
- Year:
- 2 002
- Bibliographic source:
- International Journal of Clinical Pharmacology and Therapeutics 40(1): 41-46
Materials and methods
- Type of study / information:
- urinary excretion
- Endpoint addressed:
- basic toxicokinetics
- Principles of method if other than guideline:
- urinary excretion of two exposed male workers was monitored
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3,4-dichloroaniline
- EC Number:
- 202-448-4
- EC Name:
- 3,4-dichloroaniline
- Cas Number:
- 95-76-1
- Molecular formula:
- C6H5Cl2N
- IUPAC Name:
- 3,4-dichloroaniline
- Details on test material:
- no data
Constituent 1
Method
- Ethical approval:
- confirmed, but no further information available
- Details on study design:
- urinary 3,4-DCA-content of two male non-smoking workers, dealing with 3,4-DCA, was monitored before and after the end of an 8 h shift over a period of 147 or 161 days
- Exposure assessment:
- estimated
- Details on exposure:
- TYPE OF EXPOSURE: occupational at 8 h work shift in chemical factory
TYPE OF EXPOSURE MEASUREMENT: Biomonitoring (urine)
EXPOSURE PERIOD: 147 or 161 days
DESCRIPTION / DELINEATION OF EXPOSURE GROUPS / CATEGORIES: non-smoking male
Results and discussion
Any other information on results incl. tables
workers were absorbing 3,4 -DCA during their shift as the urinary detection of the parent compound was in most cases lower before the shift than after. 3,4-DCA was not detected in urinary samples of unexposed controls.
Applicant's summary and conclusion
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