Registration Dossier
Registration Dossier
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EC number: 202-448-4 | CAS number: 95-76-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable, well documented publication, which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Development and evaluation of an HPLC urinalysis screening test of occupational exposure to 3,4- and 3,5-dichloroanilines
- Author:
- El Marbough, L. et al.
- Year:
- 2 002
- Bibliographic source:
- International Journal of Clinical Pharmacology and Therapeutics 40(1): 41-46
Materials and methods
- Type of study / information:
- urinary excretion
- Endpoint addressed:
- basic toxicokinetics
- Principles of method if other than guideline:
- urinary excretion of two exposed male workers was monitored
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3,4-dichloroaniline
- EC Number:
- 202-448-4
- EC Name:
- 3,4-dichloroaniline
- Cas Number:
- 95-76-1
- Molecular formula:
- C6H5Cl2N
- IUPAC Name:
- 3,4-dichloroaniline
- Details on test material:
- no data
Constituent 1
Method
- Ethical approval:
- confirmed, but no further information available
- Details on study design:
- urinary 3,4-DCA-content of two male non-smoking workers, dealing with 3,4-DCA, was monitored before and after the end of an 8 h shift over a period of 147 or 161 days
- Exposure assessment:
- estimated
- Details on exposure:
- TYPE OF EXPOSURE: occupational at 8 h work shift in chemical factory
TYPE OF EXPOSURE MEASUREMENT: Biomonitoring (urine)
EXPOSURE PERIOD: 147 or 161 days
DESCRIPTION / DELINEATION OF EXPOSURE GROUPS / CATEGORIES: non-smoking male
Results and discussion
Any other information on results incl. tables
workers were absorbing 3,4 -DCA during their shift as the urinary detection of the parent compound was in most cases lower before the shift than after. 3,4-DCA was not detected in urinary samples of unexposed controls.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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