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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: acceptable, well documented publication, which meets basic scientific principles

Data source

Reference
Reference Type:
publication
Title:
Development and evaluation of an HPLC urinalysis screening test of occupational exposure to 3,4- and 3,5-dichloroanilines
Author:
El Marbough, L. et al.
Year:
2002
Bibliographic source:
International Journal of Clinical Pharmacology and Therapeutics 40(1): 41-46

Materials and methods

Type of study / information:
urinary excretion
Endpoint addressed:
basic toxicokinetics
Principles of method if other than guideline:
urinary excretion of two exposed male workers was monitored
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Method

Ethical approval:
confirmed, but no further information available
Details on study design:
urinary 3,4-DCA-content of two male non-smoking workers, dealing with 3,4-DCA, was monitored before and after the end of an 8 h shift over a period of 147 or 161 days
Exposure assessment:
estimated
Details on exposure:
TYPE OF EXPOSURE: occupational at 8 h work shift in chemical factory
TYPE OF EXPOSURE MEASUREMENT: Biomonitoring (urine)
EXPOSURE PERIOD: 147 or 161 days
DESCRIPTION / DELINEATION OF EXPOSURE GROUPS / CATEGORIES: non-smoking male

Results and discussion

Any other information on results incl. tables

workers were absorbing 3,4 -DCA during their shift as the urinary detection of the parent compound was in most cases lower before the shift than after. 3,4-DCA was not detected in urinary samples of unexposed controls.

Applicant's summary and conclusion