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EC number: 202-448-4
CAS number: 95-76-1
During the range finding test for the challenge concentration acute
dermal toxicity was observed after simultaneous exposure of each of five
guinea pigs to 4 occlusive gauze patches treated with either 0.5 mL 6,
12, 25 or 50 % 3,4 -dichloroaniline in propylene glycol.Two animals were
found dead after 24 h and the remaining three were euthanized for animal
welfare reasons due to severe signs of toxicity.
Diesing, L, 1990
3,4 -dichloroaniline was tested for skin sensitisation according to OECD
guideline 406 in a Magnusson and Kligman test in male guinea pigs.
Although irritation was also evident in the control group after
challenge or rechallenge with either 50, 25 or 5 % 3,4 -dichloroaniline
in propylene glycol (w/w) the incidence and severity of irritation was
always higher in the induced test group. Therefore 3,4 -dichloroaniline
was categorised as sensitising.
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