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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
repeated dose toxicity: dermal
Remarks:
other: no data, migrated data set
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original report not yet available, migrated data set

Data source

Reference
Reference Type:
secondary source
Title:
Substituted Anilines Task Force:unpublished draft,72 pages (12.07.1983)
Author:
Du Pont Company Data (no date)
Bibliographic source:
Cited in: Rautio: Synthetic Organic Chemical Manufactures Association

Materials and methods

Principles of method if other than guideline:
Method: other: no data , migrated data set
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
3,4-dichloroaniline
EC Number:
202-448-4
EC Name:
3,4-dichloroaniline
Cas Number:
95-76-1
Molecular formula:
C6H5Cl2N
IUPAC Name:
3,4-dichloroaniline
Details on test material:
IUCLID4 Test substance: no data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on exposure:
Route of Administration: dermal
Duration of treatment / exposure:
2 weeks, 6 h/d
Frequency of treatment:
5 d/week
Doses / concentrationsopen allclose all
Remarks:
Doses / Concentrations:
60 mg/kg bw
Basis:

Remarks:
Doses / Concentrations:
135 mg/kg bw
Basis:

No. of animals per sex per dose:
no data
Control animals:
other: no data

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

low dose: Skin irritation, no other pathophysiological changes, increase in methemoglobin formation, reduction of erythrocytes and hemoglobin.

high dose: after 6 to 8 days 50 % of the animals were dead, increase in methemoglobin and glutamat pyruvat transaminase,reduction of erythrocytes and hemoglobin.

Applicant's summary and conclusion