Registration Dossier
Registration Dossier
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EC number: 202-448-4 | CAS number: 95-76-1
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- repeated dose toxicity: dermal
- Remarks:
- other: no data, migrated data set
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original report not yet available, migrated data set
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Substituted Anilines Task Force:unpublished draft,72 pages (12.07.1983)
- Author:
- Du Pont Company Data (no date)
- Bibliographic source:
- Cited in: Rautio: Synthetic Organic Chemical Manufactures Association
Materials and methods
- Principles of method if other than guideline:
- Method: other: no data , migrated data set
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3,4-dichloroaniline
- EC Number:
- 202-448-4
- EC Name:
- 3,4-dichloroaniline
- Cas Number:
- 95-76-1
- Molecular formula:
- C6H5Cl2N
- IUPAC Name:
- 3,4-dichloroaniline
- Details on test material:
- IUCLID4 Test substance: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- 2 weeks, 6 h/d
- Frequency of treatment:
- 5 d/week
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
60 mg/kg bw
Basis:
- Remarks:
- Doses / Concentrations:
135 mg/kg bw
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- other: no data
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
low dose: Skin irritation, no other pathophysiological changes, increase in methemoglobin formation, reduction of erythrocytes and hemoglobin.
high dose: after 6 to 8 days 50 % of the animals were dead, increase in methemoglobin and glutamat pyruvat transaminase,reduction of erythrocytes and hemoglobin.
Applicant's summary and conclusion
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