Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-448-4
CAS number: 95-76-1
Guilhermino, L. et al. 1998
The aim of this study was the evaluation of the acute effects of
3,4-dichloroaniline injection (i.p.) in male Wistar rats on blood
Therefore groups of 8 male Wistar rats were injected 1 mL sesame oil
with either 0, 81, 162, 324, 486 and 568 mg
3,4-dichloroaniline/ kg bw. The mortality within 24 h, blood parameters,
relative organ weights and morphology were determinded. The observed
LOEL was 324 mg/ kg bw. Higher doses caused hyperthrophy of spleen,
thymus and kidney, as well as an increase of neutrophils and a reduction
of leukocytes and lymphocytes. Furthermore the dose-dependent induction
of methemoglobin formation indicated hematotoxicity. Histopathological
changes of the blood were the formation of giant platelets and red blood
cell polychromasia indicating accelerated trombopoiesis caused by
spleenic lesions. Nephrotoxicity is indicated by the increase of urea
and creatinine as well as the kidney-hypertrophy. Methemoglobin
formation is the most sensitive parameter resulting from
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again