Registration Dossier
Registration Dossier
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EC number: 202-448-4 | CAS number: 95-76-1
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer reviewed data cited in EU risk assessment report
Data source
Referenceopen allclose all
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 990
- Reference Type:
- review article or handbook
- Title:
- European Union Risk Assessment Report: 3,4-dichloraniline (3,4-DCA), Vol. 65
- Author:
- European Chemicals Bureau
- Year:
- 2 006
- Bibliographic source:
- EU RAR: 3,4-dichloraniline (3,4-DCA), Vol. 65; EUR 22235 EN ISSN 1018-5593
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3,4-dichloroaniline
- EC Number:
- 202-448-4
- EC Name:
- 3,4-dichloroaniline
- Cas Number:
- 95-76-1
- Molecular formula:
- C6H5Cl2N
- IUPAC Name:
- 3,4-dichloroaniline
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test organisms
- Test organisms (species):
- activated sludge
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 3 h
- Dose descriptor:
- EC10
- Effect conc.:
- < 18 mg/L
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 44 mg/L
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- other: EC80
- Effect conc.:
- 160 mg/L
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
Applicant's summary and conclusion
- Executive summary:
Hoechst AG (1990)
The EC50 (3 h) for O2 -consumption (respiration rate) of activated sludge determined according to OECD Guideline 209 was determined to be 44 mg/L. Furthermore, an EC10 < 18 mg/L and an EC80 = 160 mg/L were determined.
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