Registration Dossier

Ecotoxicological information

Toxicity to microorganisms

Currently viewing:

Administrative data

Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: peer reviewed data cited in EU risk assessment report

Data source

Referenceopen allclose all

Reference Type:
other company data
Title:
Unnamed
Year:
1990
Reference Type:
review article or handbook
Title:
European Union Risk Assessment Report: 3,4-dichloraniline (3,4-DCA), Vol. 65
Author:
European Chemicals Bureau
Year:
2006
Bibliographic source:
EU RAR: 3,4-dichloraniline (3,4-DCA), Vol. 65; EUR 22235 EN ISSN 1018-5593

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
3,4-dichloroaniline
EC Number:
202-448-4
EC Name:
3,4-dichloroaniline
Cas Number:
95-76-1
Molecular formula:
C6H5Cl2N
IUPAC Name:
3,4-dichloroaniline
Details on test material:
IUCLID4 Test substance: as prescribed by 1.1 - 1.4

Sampling and analysis

Analytical monitoring:
no

Test organisms

Test organisms (species):
activated sludge

Results and discussion

Effect concentrationsopen allclose all
Duration:
3 h
Dose descriptor:
EC10
Effect conc.:
< 18 mg/L
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Duration:
3 h
Dose descriptor:
EC50
Effect conc.:
44 mg/L
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Duration:
3 h
Dose descriptor:
other: EC80
Effect conc.:
160 mg/L
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate

Applicant's summary and conclusion

Executive summary:

Hoechst AG (1990)

The EC50 (3 h) for O2 -consumption (respiration rate) of activated sludge determined according to OECD Guideline 209 was determined to be 44 mg/L. Furthermore, an EC10 < 18 mg/L and an EC80 = 160 mg/L were determined.