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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Description of key information

Effective concentration (EC50) value of N,N-dimethyl-p-toluidine to Daphnia magna in 48 hrs study on the basis of motality effect was examined at dose concentration 23.758 mg/L. This Value indicates that N,N-dimethyl-p-toluidine is toxic to Daphnia magna in chronic category 3.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
23.758 mg/L

Additional information

Based on the various studies available with Klimish rating 2 and 4 for target chemical CAS NO 99-97-5 and the read across substances . The results is summarized as follows

 

Sr.No

Endpoint

Effect values

Basis for effects

Duration

Species

Remarks

1

LC50

15.259 mg/l

mortality

48 hrs

Daphnia magna

Predicted data for target chemical

2

EC50

23.758 mg/L.

 

mortality

48 hrs

Daphnia magna

Data from database

3

EC50

13.7 mg/L.

 

mortality

48 hrs

Daphnia magna

Data from publication for CAS no 121-69-7

 

By applying weight of evidence approach to the studies summarized in the above table, the EC50 value is expected to be in range of 13.7 to 23.758 mg/l and LC50 value was found to be 15.259 mg/l in 48 hrs study on the basis of mortality effect. Since N,N-dimethyl-p-toluidine is not found to be rapidly degradable. Thus according to CLP criteria of aquatic classification it is concluded that the substance N,N-dimethyl-p-toluidine is toxic to aquatic invertebrate (Daphnia magna)in aquatic chronic category 3