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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Description of key information

Effective concentration (EC50) value of N,N-dimethyl-p-toluidine to green algae in 96 hrs study on the basis of motality effect was examined at dose concentration 15.481 mg/L. This Value indicates that N,N-dimethyl-p-toluidine is toxic to Daphnia magna in chronic category 3.

Key value for chemical safety assessment

EC50 for freshwater algae:
15.481 mg/L

Additional information

Based on the various studies available with Klimish rating 2 and 4 for the target substance CAS NO 99-97-8 and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No

Endpoint

Effect values

Basis for effects

Duration

Species

Remarks

1

EC50

15.481

 mg/l

growth rate

96 hrs hrs

Green algae

Data is from database

2

EC50

24.37mg/l

Growth

72 hrs

Pseudokirchneriella subcapitata

Predicted data of target chemcial 

3

EC50

22 mg/l

growth rate

72 hrs

Chlorella pyrenoidosa

Data from publication for CAS no 121-69-7

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that EC50 value is expected to be in range of15.481 to24.37 mg/l in 72 hrs to 96 hrs study on the basis of growth rate. Since substance was not found to be rapidly degradable.Thus considering CLP Criteria for aquatic classification of the substance, it is concluded that N,N-dimethyl-p-toluidine does exhibit toxicity to (green algae, Pseudokirchnerella subcapitata, Chlorella pyrenoidosa) in aquatic chronic category 3