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Toxicity to microorganisms

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Description of key information

The predicted value of IGC50 of N,N-dimethyl-p-toluidine on Tetrahymena pyriformis is 80.53 mg/l at 48 hrs. 

Key value for chemical safety assessment

EC50 for microorganisms:
13.6 mg/L

Additional information

Based on the various studies available with Klimish rating 2 and 4 for the target substance CAS NO 99-97-8 and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No

Endpoint

Effect values

Basis for effects

Duration

Species

Remarks

1

IGC50

80.53

mg/l

growth inhibition

48 hrs

Tetrahymena pyriformis

 

Predicted data for target chemical

2

EC50

 

 

 

161.2

 mg/l

 

 

 

growth inhibition

24 hrs

Tetrahymena pyriformis

 

Predicted data for target chemical

3

EC50

 

 

 

42.86

 mg/l

 

 

 

growth inhibition

48 hrs

Tetrahymena pyriformis

 

Predicted data for target chemical

4

IGC50

32.6

mg/l

growth inhibition

48 hrs

Tetrahymena pyriformis

 

Data from publication for CAS no 91-66-7

5

EC50

 

13.6 mg/L

 

reduction in light emission

30 min

Photobacterium phosphoreum

Data from publication for CAS no 121-69-7

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that EC50 value is expected to be in the range of 13.6 to 161.2 mg/l based on the growth inhibition effect for various duration starting from 30 mins till 48 hours.