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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
RTECS Number: XU5803000
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances):- TOVEFN Toksikologicheskii Vestnik.Volume(issue)/page/year: (2),44,2006; TOVEFN Toksikologicheskii Vestnik. Volume(issue)/page/year: (4),30,2007

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
standard acute method
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: N,N-dimethyl-p-toluidine
- Molecular formula: C9H13N
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
unchanged (no vehicle)
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
139 mg/kg bw
Based on:
test mat.
Clinical signs:
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression.

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Oral toxicity effect as expressed as LD50 to mouse for N,N-dimethyl-p-toluidine was examined at dose concentration of 139 mg/kg of body weight . The substance is reported to cause somnolence (general depressed activity) induce respiratory depression and has effect on lungs, thorax.These results suggest that the N,N-dimethyl-p-toluidine is toxic to mouse via oral route of exposure and falls under acute oral category 3.
Executive summary:

Oral toxicity effect as expressed as LD50 to mouse for N,N-dimethyl-p-toluidine was examined at dose concentration of 139 mg/kg of body weight . The substance is reported to cause somnolence (general depressed activity) induce respiratory depression and has effect on lungs, thorax.These results suggest that the N,N-dimethyl-p-toluidine is toxic to mouse via oral route of exposure and falls under acute oral category 3.