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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

Lethal concentration (LC50) value of N,N-dimethyl-p-toluidine to fish (Pimephales promelas) in 96 hours study on the basis of motality effect was examined at dose concentration 52.8 mg/L. This Value indicates that N,N-dimethyl-p-toluidine is toxic to fish (Pimephales promelas) in chronic category 3.

Key value for chemical safety assessment

LC50 for freshwater fish:
52.8 mg/L

Additional information

Based on the various studies available with Klimish rating 2 for the target substance CAS NO 99-97-8 The results is summarized as follows

Sr.No

Endpoint

Effect values

Basis for effects

Duration

Species

Remarks

1

TLm

44 mg/l

mortality

24 hrs

Oryzias latipes

Data from publication for target chemical

2

TLm

20 mg/l

mortality

24 hrs

Oryzias latipes

Data from publication for target chemical

3

LC50

52.8 mg/l

mortality

96hrs

Pimephales promelas

Data from publication for target chemical

4

LC50

EC50

52 mg/l

52 mg/l

mortality

96hrs

Pimephales promelas

Data from publication for target chemical

3

LC50

EC50

46 mg/l

41.5 mg/l

mortality

96hrs

Pimephales promelas

Data from publication for target chemical

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that the LC50 values was found to be in range of 46 to 52 mg/l in 96 hrs and the EC50 values was found to be in the range of 41.5 to 52 mg/l in 96 hrs. Also the Median Tolerence limit (TLm) value was found to be in the range of 20 to 44 mg/l in 24 hrs study on the basis of mortality effect. Since the substance was not found to be rapidly degradable. Thus considering the CLP Criteria for aquatic classification of the substance, it is concluded that N,N-dimethyl-p-toluidine exhibit short term toxicity to fish (Oryzias latipes,Pimephales promelas) in aquatic chronic category 3.