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EC number: 202-805-4 | CAS number: 99-97-8
In Treated area Dose:0.5 ml of test item Sex:Female
In Control area Dose:0.5 ml of distilled water Sex:Female
Key:h = Hour.
0 =No erythema 0 =No oedema
1 = Very slight erythema (barely perceptible) 1 = Very slight oedema(barely perceptible)
Mean Individual Animal Score at 24, 48 and 72 hours
Body Weight (kg)
Prior to Dosing
Key: kg = kilogram
Days (Post dosing Observation)
Key: ./. = Not Applicable. 1 = Normal.
Acute Dermal Irritation/corrosion Study of N, N-dimethyl-p-toluidine in Rabbits was performed as per OECD guideline No. 404. Three healthy young adult female rabbits were used. Rabbits with good intact skin were selected for the study. The hairs of all the rabbits were clipped at contralateral sites, approximately 24 hours prior to treatment.A dose of0.5 ml of test item (as such) wasappliedto the skin,over an area of approximately 6 x 6 cm clippedof haironone side of rabbits.The other untreated side was kept as control area and0.5 ml of distilled water was applied at this site. At the end of 4 hours, the gauze patch was removed and test item application site was wiped with water without altering the integrity of the epidermis. Animal No. 2, revealed very slight erythema (barely perceptible) and very slight oedema (barely perceptible) observed at 1 hour of observationpost patch removal. At 24 hour well defined erythema andvery slight oedema (barely perceptible) was observed. At 48 hour very slight erythema (barely perceptible) and no oedema was observed. At 72 hour no erythema and no oedema was observed. Animal No. 3, revealed very slight erythema (barely perceptible) and very slight oedema (barely perceptible) observed at 1 hour of observationpost patch removal. At 24 hourvery slight erythema (barely perceptible)andno oedema was observed. At 48 and 72 hour no erythema and no oedema was observed.The patch was removed after 4 hours and rabbits wereobservedfor erythema and oedemaat 1, 24, 48 and 72 hours after patch removal, evaluatedand graded as per draize method.
Initially, the test item was applied to the clipped area of skin of one rabbit. The test site was covered with gauze patch.After 4 hours of exposure in animal no. 1, very slight erythema (barely perceptible) and very slight oedema (barely perceptible) observed at 1 hour of observation. At 24 hour very slight erythema (barely perceptible) and no oedema was observed.Hence the confirmatory test was conducted after 24 hours on additional two rabbits (No. 2 and 3)to confirm the non irritant nature of the test item. At 48 and 72 hours observation no erythema and no oedema was observed in animal no 1. Hence, under the experimental conditions tested it is concluded that N, N-dimethyl-p-toluidine was Non-Irritating to the skin of female New Zealand White rabbits and Classified as “Category- Not Classified as Skin Irritant" as pre CLP criteria
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