Registration Dossier
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EC number: 202-805-4 | CAS number: 99-97-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
Physical and Chemical properties :
Appeareance / physical state / colour :
On the basis of physical observation and using the sense of smell, N,N-dimethyl-p-toluidine was found to be brown coloured organic liquid having unpleasant odour.
Freezing Point :
Freezing point of N,N-dimethyl-p-toluidine was found to be -15 deg C.
Supporting studies shows value different from key study which could be due to difference in the estimation conditions. However for the purpose of chemical safety assessment key study value -15 deg C shall be considered.
Boiling Point :
The experimental value of boiling point of N,N-dimethyl-p-toluidine by distillation method was found to be 211.2°C at atmospheric pressure of 965 hpa. No decomposition of N,N-dimethyl-p-toluidine was observed at the boiling point.
Supporting studies shows value different from key study which could be due to difference in the estimation conditions. However for the purpose of chemical safety assessment key study value 211.2 deg C shall be considered.
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Density :
Bulk density of N,N-dimethyl-p-toluidine as measured by mass by volume method was found to be 0.88 g/cm³ at temperature 35 °C.Supporting studies shows value different from key study which could be due to difference in the estimation conditions. However for the purpose of chemical safety assessment key study value 0.88 g/cm3 shall be considered.
Particle size distribution (Granulometry) :
In accordance with column 2 of Annex VII of the REACH regulation, testing for particle size analysis is not required for those substances which are marketed or used in a non solid or non granular form. Since N,N-dimethyl-p-toluidine is a liquid as mentioned in the section 4.1 of this registration dossier, this end point was considered for waiver.
Vapour pressure :
Vapour Pressure of N,N-dimethyl-p-toluidine was found to be 0.07501 mmHg at 20 deg C.This value when converted into Pascal is equivalent to 10 pa at 20 deg C.Supporting studies shows value different from key study which could be due to difference in the estimation conditions. However for the purpose of chemical safety assessment key study value 10 Pa shall be considered.
Partition coefficient :
The experimental value of octanol water partition co-efficient (log Pow) of ofN,N-dimethyl-p-toluidineby Shake flask method was found to be 1.729 at temperature 35 deg C and pH of 5.6. This value indicates that the substance N,N-dimethyl-p-toluidine is hydrophobic in nature
Supporting studies shows value different from key study which could be due to difference in the estimation conditions. However for the purpose of chemical safety assessment key study value 1.729 shall be considered.
Water solubility :
Water solubility of N,N-dimethyl-p-toluidine was found to be 650 mg/L at Temperature of 37 °C . This value indicates that N,N-dimethyl-p-toluidine is moderately soluble in water.
The supporting studies also shows water solubility of N,N-dimethyl-p-toluidine to be moderately soluble.
Solubility in organic solvent / fat solubility :
The experimental value of solubility of N,N-dimethyl-p-toluidine in petroleum ether at temperature of 35 deg C was found to be 180000 mg/L indicating that N,N-dimethyl-p-toluidine is very soluble in petroleum ether and the experimental value of solubility of N,N-dimethyl-p-toluidine in methanol at temperature of 35 deg C was found to be 120000 mg/L indicating that N,N-dimethyl-p-toluidine is very soluble in methanol.
Surface tension :
Surface Tension of N,N-dimethyl-p-toluidine was estimated as 33.97 mN/m by using Chemspider - ACD/PhysChem Suite.
Flash point :
Experimetnal value for flash point of N,N-dimethyl-p-toluidine by using closed cup method was found to be 87°C at atmospheric pressure of 965 hPa.
Supporting studies shows value different from key study which could be due to difference in the estimation conditions. However for the purpose of chemical safety assessment key study value 87 deg C shall be considered.
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Autoflammability :
N,N-dimethyl-p-toluidinedid not catch fire on being exposed to air at room temperature of 35 deg C and atmospheric pressure of 965 hPa. This indicatesN,N-dimethyl-p-toluidineis not auto-flammable.
Flammability :
From the experimental values of flammability,N,N-dimethyl-p-toluidineignited when the flame of Bunsen burner having temperature of 950 deg C was brought in contact with it. Thus it can be concluded thatN,N-dimethyl-p-toluidineis flammable only at high temperature of about 950 deg C. However since such high temperatures are not found under normal circumstances of transportation and use, N,N-dimethyl-p-toluidine was considered non-flammable for chemical safety assessment.
Explosiveness :
Based on the chemical structure, N,N-dimethyl-p-toluidine does not possess explosive properties as there are no chemical groups associated with explosive properties in the molecule. Thus, in accordance with column 2 of Annex VII this end point was considered for waiver.
Oxidizing properties :
N,N-dimethyl-p-toluidinewas found to be oxidising since102.3 ml of KMnO4 was required for getting the end point of the redox titration for 100 g ofN,N-dimethyl-p-toluidine.
Stability in organic solvent and identity of relevent degradation products :
N,N-dimethyl-p-toluidinewas found to be stable in organic solvent dichloro methane and no degradation products were formed after 24 hours as evident from the GC-MS chromatogram obtained at 0 hours and that obtained after 24 hours.
pH :
1% by volume solution ofN,N-dimethyl-p-toluidinewas found to exhibit a pH of 7.44 at 25deg C. Thus 1% by volume solution ofN,N-dimethyl-p-toluidineis neutral in nature.
Dissociation constant :
The experimental pKa value for N,N-dimethyl-p-toluidine was found to be 0.05497 (average pKa value) at 35 deg C indicating that the chemical has dissociation properties.
Viscosity :
Experimental value of viscosity of N,N-dimethyl-p-toluidine by Redwood/ Ostwald Viscometer method was found to be 14.4 mPa s (dynamic) at 35 deg C.
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