Registration Dossier
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EC number: 202-805-4 | CAS number: 99-97-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Classification of N,N-dimethyl-p-toluidine for effects in the environment
Several major guideline – estimation values (Klimisch 2) are available for N,N-dimethyl-p-toluidine, which indicates substantial toxic effect on invertebrates and algae when exposed to the substance, N,N-dimethyl-p-toluidine at concentrations up to its limit of solubility in the respective test media. Among the values lower values which lead to the classification of the substance the value which have been considered for further calculation (invertebrate) is EC50 = 13.7 mg/L.
In determining the classification appropriate to N,N-dimethyl-p-toluidine, it is necessary to consider all available evidence concerning its persistence, potential to accumulate and predicted or observed environmental fate and behaviour that may present a long-term and/or delayed danger to the structure and/or functioning of aquatic ecosystems. These points are considered below.
Persistence
Reliable studies are available to demonstrate that N,N-dimethyl-p-toluidine is persistent in nature and so is considered to be non biodegradable in the environment. In other words N,N-dimethyl-p-toluidine may therefore be expected to degrade slowly. Thus it can be inferred that N,N-dimethyl-p-toluidine is persistent in nature.
N,N-dimethyl-p-toluidine is persistent (P).
Potential to accumulate
Predicted and measured log Kow values for N,N-dimethyl-p-toluidine are less than 4 (Log Kow = 1.729). thus, the potential for N,N-dimethyl-p-toluidine to bioaccumulate in the tissues of organisms that inhabit aquatic or terrestrial matrices is considerable though the BCF factor for the substance is less than 1000.
N,N-dimethyl-p-toluidinedoes not satisfy the criterion for classification as bioaccumulative (B).
The toxicity values (EC 50) of fish, invertebrates and algae 41.5 mg/L, 13.7 mg/L are 15.481 mg/L, respectively. The values of all the 3 trophic levels (fish, invertebrate and algae) fall in the criteria for classification (CLP regulation) and so will qualify for classification as per the CLP regulation in the criteria of category 3 due to non biodegradable criteria as well.
N,N-dimethyl-p-toluidinesatisfies the environmental effects criterion for classification as toxic (T).
N,N-dimethyl-p-toluidineis therefore will not be B substance, but will qualify as P and T. But as per Annex XIII of the REACH regulation the chemical will not quality as PBT
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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