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EC number: 202-805-4 | CAS number: 99-97-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from Environmental Molecular Mutagenesis
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
- Species / strain / cell type:
- S. typhimurium, other: TA 97,TA 98,TA 100
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- 0, 1, 2.5, 5, 10, 40, 70, 100 ug/plate
- Species / strain:
- S. typhimurium, other: TA 97,TA 98, TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- Cytotoxic Concentration: 100 ug/plate
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
- Conclusions:
- Interpretation of results (migrated information):
negative
Bacterial reverse mutation at dose concentration of 0-100 UG/PLATE of N,N-dimethyl-p-toluidine with and without metabolic activation to S. typhimurium TA 97,TA 98, TA 100 was examined as NEGATIVE. - Executive summary:
- Bacterial reverse mutation at dose concentration of 0-100 UG/PLATE of N,N-dimethyl-p-toluidine with and without metabolic activation to S. typhimurium TA 97,TA 98, TA 100 was examined as NEGATIVE.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Based on studies of target substance CAS NO 99-97-8 reviewed for genetic toxicity from reliable sources having Klimisch rating 2 and 4 based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows.
The summary of the results are presented below
Sr. No |
End point |
Effect |
Species
|
Remarks |
1 |
In vitro Genetic toxicity
|
Negative with and without metabolic activation
|
S. typhimurium TA 97,TA 98, TA 100
|
Data is from publication for target chemical |
2 |
In vitro Genetic toxicity
|
Negative with and without metabolic activation S9 derived from induced hamster or rat liver.
|
S. typhimurium strains TA97, TA98, TA100, or TA1535
|
Data is from study for target chemical |
3 |
In vitro Genetic toxicity
|
negative with and without 10% rat liver S9 for exogenous metabolic activation |
S. typhimurium strains TA98 and TA100 and E. coli WP2 uvr A pKM 101 |
Data is from study for target chemical |
4 |
chromosome aberration |
negative without metabolic activation |
B6C3F1/N mice micronucleated erythrocytes |
Data is from study for target chemical |
5 |
In vitro Genetic toxicity
|
negative with and without metabolic activation |
S. typhimurium strains TA 98, TA 1537, TA 1538, TA 100 |
Data is from study for target chemical |
6 |
chromosome aberration |
negative with metabolic activation |
Chinese hamster Lung |
Predicted data for target chemical |
7 |
chromosome aberration |
negative without metabolic activation |
Chinese hamster Lung |
Predicted data for target chemical |
Based on the results summarized in above table for the target chemical CAS NO 99-97-8, it can be concluded that the substance is non-genotoxic with and without metabolic activation.Thus N,N-dimethyl-p-toluidine is considered to be non-genetic toxic as per CLP criteria.
Justification for selection of genetic toxicity endpoint
Bacterial reverse mutation at dose concentration of 0-100 UG/PLATE of N,N-dimethyl-p-toluidine with and without metabolic activation to S. typhimurium TA 97,TA 98, TA 100 was examined as NEGATIVE.
Justification for classification or non-classification
From the above studies it can be concluded that the substance N,N-dimethyl-p-toluidine is not genotoxic
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