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Diss Factsheets

Environmental fate & pathways

Hydrolysis

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
experimental data of read across substances
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report was prepared based on two hydrolysis studies.
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
yes
Remarks:
WoE 3
Temp.:
25 °C
Remarks:
WoE 2. The study was performed at pH 4, 7 and 9, respectively.
Duration:
5 d
Temp.:
50 °C
Initial conc. measured:
20 mg/L
Remarks:
WoE 3. The study was performed at pH 4, 7 and 9, respectively.
Number of replicates:
WoE 2. No data available
WoE 3. 2 replicates/pH solution
Positive controls:
not specified
Negative controls:
not specified
Transformation products:
not specified
Key result
Temp.:
25 °C
DT50:
> 1 yr
Remarks on result:
other: WoE 2. The study was performed at pH 4, 7 and 9, respectively.
Temp.:
50 °C
Remarks on result:
other: WoE 3. Although the half-life value of test chemical was not known, but at the preliminary test, the residues of the test chemical were more than 90 % in all the pH. Thus, the test chemical was reported to be stable in water.
Details on results:
WoE 2. The half-life value of test chemical was determined to be > 1 yr at pH 4, 7 and 9, respectively at a temperature of 25⁰C. Thus, the test chemical was reported to be hydrolytically stable.
WoE 3. The residues of the test chemical were more than 90 % in all the pH. Thus, the test chemical was reported to be stable in water.
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of the experimental studies and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 1 yr, at pH range 4, 7 & 9 and at a temperature of 25°C or 50°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical was non hydrolysable in water.

Executive summary:

Data from various sources for the test chemical were reviewed for the hydrolysis end point study which are summarized as below:

 

The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 25°C and pH of 4, 7 and 9, respectively. The half-life value of test chemical was determined to be > 1 yr at pH 4, 7 and 9, respectively at a temperature of 25⁰ C. Thus, based on this result, test chemical was considered to be non-hydrolysable.

 

Above data further supported by the data obtained from the secondary sources. The half-life of the test chemical was determined at different pH range. The preliminary study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C. Initial test chemical concentration used for the study was 20 mg/l. Analytical method involve the use of HPLC. Although the half-life value of test chemical was not known, but at the preliminary test, the residues of the test chemical were more than 90 % in all the pH. Thus, the test chemical was reported to be stable in water at a temperature of 50 ⁰ C and at pH 4, 7 and 9, respectively. Based on the half-life values, it was concluded that the test chemical was non hydrolysable.

 

Thus, based on the above all studies and result observation, test chemical was considered to be non-hydrolysable.  

Description of key information

On the basis of the experimental studies and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 1 yr, at pH range 4, 7 & 9 and at a temperature of 25°C or 50°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical was non hydrolysable in water.

Key value for chemical safety assessment

Additional information

Data from various sources for the test chemical and structurally and functionally similar read across chemicals were reviewed for the hydrolysis end point study which are summarized as below:

 

The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 25°C and pH of 4, 7 and 9, respectively. The half-life value of test chemical was determined to be > 1 yr at pH 4, 7 and 9, respectively at a temperature of 25⁰ C. Thus, based on this result, test chemical was considered to be non-hydrolysable.

 

Above data further supported by the data obtained from the secondary sources. The half-life of the test chemical was determined at different pH range. The preliminary study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C. Initial test chemical concentration used for the study was 20 mg/l. Analytical method involve the use of HPLC. Although the half-life value of test chemical was not known, but at the preliminary test, the residues of the test chemical were more than 90 % in all the pH. Thus, the test chemical was reported to be stable in water at a temperature of 50 ⁰ C and at pH 4, 7 and 9, respectively. Based on the half-life values, it was concluded that the test chemical was non hydrolysable.

 

Thus, based on the above all studies and result observation, test chemical was considered to be non-hydrolysable.