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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
RTECS Number: XU5803000
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances):- HPV300 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Monocyclic Aromatic Amines (MAA) Category.pdf http://www.epa.gov/HPV/pubs/summaries/aroamin/c13310tc.htm; 2001
Reference Type:
other: Authoritative data base
Title:
GCID 397422
Year:
2011
Bibliographic source:
ACToR (Aggregated Computational Toxicology Resource),ChemFirst Study No. 3888-91-0106-TX-001
Reference Type:
other: Authoritative data base
Title:
Acute Toxicity through dermal route
Year:
2012
Bibliographic source:
US EPA ,High Production Volume Information System (HPVIS),ChemFirst Study No. 3888-91-0106-TX-001

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: N,N-dimethyl-p-toluidine
- Molecular formula: C9H13N
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
not specified
Vehicle:
other: neat
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Details of toxic effects not reported other than lethal dose value
Mortality:
50 percent kill
Clinical signs:
Details of toxic effects not reported other than lethal dose value.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The lethal dose value (LD50) for N.N-dimethyl-p-toluidine in rabbit is reported as >2000 mg/kg via dermal route of exposure.
Executive summary:

Dermal toxicity (LD50) of N,N-dimethyl-p-toluidine was examined in rabbit at dose concentration of >2000 mg/kg of skin exposure. Details of toxic effects not reported other than lethal dose value. These results suggest that the N,N-dimethyl-p-toluidine is non toxic to rabbit via dermal contact. However, since this substance has a harmonized classification of exhibiting Acute Toxicity Category 3 via the dermal route; for the purpose of the chemical safety assessment and this dossier; the harmonized classification shall be adhered to.