Registration Dossier

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
RTECS Number: XU5803000
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances):- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0573706

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
standard acute method
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: N,N-dimethyl-p-toluidine
- Molecular formula: C9H13N
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Duration of exposure:
4 h
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
1 400 mg/m³ air
Based on:
test mat.
Exp. duration:
4 h
Clinical signs:
other: Sense Organs and Special Senses (Olfaction) - ulcerated nasal septum Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory stimulation

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Inhalation toxicity (LC50) of N,N-dimethyl-p-toluidine was examined in rats at a dose concentration of 1400 mg/m³ air.
Executive summary:

Inhalation toxicity (LC50) of N,N-dimethyl-p-toluidine was examined in rats at a dose concentration of 1400 mg/m³ air after 4 hours of exposure. The adverse effects due to toxicity of N,N-dimethyl-p-toluidine include ulcerated nasal septum Lungs, dyspnea Lungs and respiratory stimulation. These results suggest that the N,N-dimethyl-p-toluidine is toxic to mouse via inhalation and falls under acute inhalation category 3.