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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
other: Authoritative data base
Title:
Genetic Toxicity in vitro
Year:
2012
Bibliographic source:
US EPA ,High Production Volume Information System (HPVIS),Taningher, M. et al, (1993) Environ. Mol. Mutagen. 21: 349-356.
Reference Type:
other: Authoritative data base
Title:
GCID 397422
Year:
2011
Bibliographic source:
ACToR (Aggregated Computational Toxicology Resource),TANINGHER,M, PASQUINI,R AND BONATTI,S; GENOTOXICITY ANALYSIS OF N,N- DIMETHYLANILINE AND N,N-DIMETHYL-PTOLUIDINE; ENVIRON. MOL. MUTAGEN. 21(4):349- 356, 1993

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Bacterial reverse mutation assay.
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: N,N-dimethyl-p-toluidine
- Molecular formula: C9H13N
- Substance type: Organic
- Physical state: Liquid

Method

Species / strain
Species / strain / cell type:
S. typhimurium, other: TA 97,TA 98,TA 100
Additional strain / cell type characteristics:
not specified
Metabolic activation:
with and without
Test concentrations with justification for top dose:
0, 1, 2.5, 5, 10, 40, 70, 100 ug/plate

Results and discussion

Test results
Species / strain:
S. typhimurium, other: TA 97,TA 98, TA 100
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Additional information on results:
Cytotoxic Concentration: 100 ug/plate
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative

Bacterial reverse mutation at dose concentration of 0-100 UG/PLATE of N,N-dimethyl-p-toluidine with and without metabolic activation to S. typhimurium TA 97,TA 98, TA 100 was examined as NEGATIVE.
Executive summary:

Bacterial reverse mutation at dose concentration of 0-100 UG/PLATE of N,N-dimethyl-p-toluidine

with and without metabolic activation to S. typhimurium TA 97,TA 98, TA 100 was examined as NEGATIVE.