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Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
sub-chronic toxicity: oral
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Predicted data
Title:
R: QSAR Toolbox 2.3.0.1132 prediction for "Effect LOEL" read across evaluation for 99-97-8
Author:
Sustainability Support Services (Europe) AB
Year:
2012
Bibliographic source:
QSAR Toolbox Version 2.3

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: estimated data
Principles of method if other than guideline:
QSAR prediction is done using QSAR toolbox version 2.3
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
SMILES:c1(N(C)C)ccc(C)cc1

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Duration of treatment / exposure:
91
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 750, 1000, 3000
Basis:
no data

Results and discussion

Effect levels

Dose descriptor:
LOEL
Effect level:
201.786 mg/kg bw/day (nominal)
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: effect on body weight decrease

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables






The prediction was based on dataset comprised from the following descriptors: "effect LOEL"
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

(("a" and "b" ) and ("c" and "d" ) )

Domain logical expression index: "a"

Similarity boundary:Target: c1(N(C)C)ccc(C)cc1
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Similarity boundary:Target: c1(N(C)C)ccc(C)cc1
Threshold=80%,
Dice(Atom pairs)

Domain logical expression index: "c"

Parametric boundary:The target chemical should have a value of log Kow which is >= 2.39

Domain logical expression index: "d"

Parametric boundary:The target chemical should have a value of log Kow which is <= 3.2

Applicant's summary and conclusion

Conclusions:
Based on the QSAR prediction done for N,N-dimethyl-p-toluidine for repeated dose toxicity via oral route (by gavage) on Rat (Fischer 344) it was estimated that the LOEL value is 201.78 mg/kg bw/day for effect based on body weight decrease
Executive summary:

Based on the QSAR prediction done for N,N-dimethyl-p-toluidine for repeated dose toxicity via oral route (by gavage) on Rat (Fischer 344) it was estimated that the LOEL value is 201.78 mg/kg bw/day for effect based on body weight decrease.