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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

The toxicokinetics of triethyl phosphate and metabolism was studied in rats and mice after oral and i.p. application. The skin penetrating capacities of a series of organic phosphates were measured by using a skin model in which isolated anterior forearm stratum corneum conjunctum was used.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

Triethyl phosphate is well absorbed in the gastrointerstinal tract. A dermal absorption in vivo seems possible as indicated in the in vivo and in vitro experiments, the inhalative absorption is less important.

Within 16 hours in rats and mice 90% of the oral or ip applied dose was excreted via urine and nearly 100% of the oral or ip applied dose were excreted within 96 hours via urine. Urine of rats and mice were examined for metabolites of 32P-triethylphosphate. 32P-triethylposphate was excreted by both species as 32-diethylphosphate. As a further metabolite S-ethylcysteine was found. In neither case the trialkyl-phosphate was excreted unchanged. The average maximum steady-state rate for triethyl phosphate of penetration through isolated human skin is 0.623 x 10² µmol/cm² per min.