Triethyl phosphate

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: exploratory study

Data source

Reference

Reference Type:

publication

Title:

Organophosphate ester flame retardants and plasticizers in human placenta in Eastern China

Author:

Ding J, Xu Z, Huang W, Feng L, Yang F

Year:

2016

Bibliographic source:

Science of the Total Environment 554-555, 211-217

Materials and methods

Type of study / information:

The authors analysed 50 placentas collected in Eastern China for 12 organophosphate ester analogs and correlated the concentrations to maternal characteristics.

Endpoint addressed:

not applicable

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The authors analysed 50 placentas collected in Eastern China for 12 organophosphate ester analogs and correlated the concentrations to maternal characteristics.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Triethyl phosphate

EC Number:

201-114-5

EC Name:

Triethyl phosphate

Cas Number:

78-40-0

Molecular formula:

C6H15O4P

IUPAC Name:

triethyl phosphate

Details on test material:

content: 99.99%

Method

Exposure assessment:

measured

Results and discussion

Results:

No obvious association was observed between the total accumulation level of OPEs in placenta and maternal characteristics such as age, gestational age, previous gravidity, previous breast feeding history, and food consumption habits.

Any other information on results incl. tables

In the present study, 12 organophosphate esters (OPEs) were analyzed in human placenta for the first time to understand the accumulation characteristics of OPE in placenta. TCEP was identified as the most abundant OPE in the human placentas. The concentrations of the 9 most frequently detected OPEs (Σ9OPEs) ranged from 34.4 to 862 ng/g lipid weight (lw), with a median of 301 ng/g lw. Tri(2-chloroethyl) phosphate (TCEP) was identified as the most abundant analog,with a median concentration of 142 ng/g lw, followed by tributoxyethyl phosphate (TBEP) and triphenyl phosphate (TPhP). Triphenyl phosphate (TEP) had a median concentration of 10.2 ng/g lw.

The concentrations of OPE analogs were found to be independent of the lipid content. No obvious association was observed between the total accumulation level of OPEs in placenta and maternal characteristics such as age, gestational age, previous gravidity, previous breast feeding history, and food consumption habits.

Applicant's summary and conclusion

Conclusions:

Ding et al. (2016) analysed 12 organophosphate esters (OPEs) in 50 human placentas collected in Eastern China. The concentrations of the 9 most frequently detected OPEs (sum of 9 OPEs) ranged from 34.4 to 862 ng/g lipid weight (lw), with a median of 301 ng/g lw. Tri(2-chloroethyl) phosphate (TCEP) was identified as the most abundant analog,with a median concentration of 142 ng/g lw, followed by tributoxyethyl phosphate (TBEP) and triphenyl phosphate (TPhP, 15.1 ng/g lw). Triphenyl phosphate (TEP) had a median concentration of 10.2 ng/g lw. The concentrations of OPE analogs were found to be independent of the lipid content. No obvious association was observed between the total accumulation level of OPEs in placenta and maternal characteristics such as age, gestational age, previous gravidity, previous breast feeding history, and food consumption habits.
This study is not reliable for human risk assessment.