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Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD guideline study or GLP defined. Unpublished company data (1968).

Data source

Reference
Reference Type:
other: unpublished company data
Title:
Unnamed
Year:
1968

Materials and methods

Type of study / information:
unpublished company data
Principles of method if other than guideline:
Identification of Cholinesterase activity in plasma and erythrocytes after oral administration of TEP in Beagle dogs.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Results and discussion

Any other information on results incl. tables

 

                Inhibition of Cholinesterase in %

  Dose (mg/kg)  Dog No.:  before experimental start  after 2 h  after 6 h  after 24 h  after 3 d  after 7 d
        Plasma              
 100  35 13,7   10,3 <5   <5
 100  36  0 14,5   9,5  0
 250  41  0  22,5 53,3   27,5 10   <5
 250  41  0  50,8  48,5  35,8 12,4   <5

Erythrocytes                   

 
100   35  0  0
100  36  0  0  0
250  41   <5  10,4  9  <5
250   42  0  12  6,0  <5  <5

Applicant's summary and conclusion

Executive summary:

The activity of Cholinesterase was measured in plasma and erythrocytes of dogs treated with TEP.

TEP was administered orally in a 10% aqueous dilution and after 2, 6, 24 h, 3d and 7d the activity of Choolinesterase was measured.

Every dose was tested in two dogs.

TEP inhibits the unspecific plasma-cholinesterase in dogs after administration of 250 mg/kg bw (100 mg/kg bw showed no significant effect).

The erythrocytes-cholinesterase was not inhibited after administration of 100 or 250 mg/kg in dogs.