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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

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Administrative data

additional toxicological information
Type of information:
experimental study
Adequacy of study:
other information
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD guideline study or GLP defined. Unpublished company data (1968).

Data source

Reference Type:
other: unpublished company data

Materials and methods

Type of study / information:
unpublished company data
Principles of method if other than guideline:
Identification of Cholinesterase activity in plasma and erythrocytes after oral administration of TEP in Beagle dogs.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Triethyl phosphate
EC Number:
EC Name:
Triethyl phosphate
Cas Number:
Molecular formula:
triethyl phosphate
Details on test material:
no data

Results and discussion

Any other information on results incl. tables


                Inhibition of Cholinesterase in %

  Dose (mg/kg)  Dog No.:  before experimental start  after 2 h  after 6 h  after 24 h  after 3 d  after 7 d
 100  35 13,7   10,3 <5   <5
 100  36  0 14,5   9,5  0
 250  41  0  22,5 53,3   27,5 10   <5
 250  41  0  50,8  48,5  35,8 12,4   <5


100   35  0  0
100  36  0  0  0
250  41   <5  10,4  9  <5
250   42  0  12  6,0  <5  <5

Applicant's summary and conclusion

Executive summary:

The activity of Cholinesterase was measured in plasma and erythrocytes of dogs treated with TEP.

TEP was administered orally in a 10% aqueous dilution and after 2, 6, 24 h, 3d and 7d the activity of Choolinesterase was measured.

Every dose was tested in two dogs.

TEP inhibits the unspecific plasma-cholinesterase in dogs after administration of 250 mg/kg bw (100 mg/kg bw showed no significant effect).

The erythrocytes-cholinesterase was not inhibited after administration of 100 or 250 mg/kg in dogs.