Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Dermal absorption

Currently viewing:

Administrative data

Endpoint:
dermal absorption in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: artificial skin model - validity for human skin not evident

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Chemical structure and skin penetrating capacity of a short series of organic phosphates and phosphoric acid
Author:
Marzulli F, Callahan JF, Brown DWC
Year:
1965
Bibliographic source:
J Invest Derm, 44, 339-344
Reference Type:
publication
Title:
Die Durchlaessigkeit der Haut fuer ausgewaehlte aliphatische und alicyclische Traegersubstanzen
Author:
Meyer F, Meyer E, Kerk L
Year:
1959
Bibliographic source:
Arzneim Forsch 9, 430-432 (1959) cited in BUA report no 37
Reference Type:
review article or handbook
Title:
Triethylphosphat BUA Stoffbericht 37 (Maerz 1989)
Year:
1989
Bibliographic source:
Beratergremium für umweltrelevante Altstoffe (BUA) d. Ges. Dt. Chemiker, Weinheim, Basel (Schweiz), Cambridge, New York, NY: VCH 1989 (Bua Stoffbericht 37)

Materials and methods

Principles of method if other than guideline:
The skin penetrating capacities of a series of organic phosphates were measured by using a skin model in which isolated anterior forearm stratum corneum conjunctum was used
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Triethyl phosphate
EC Number:
201-114-5
EC Name:
Triethyl phosphate
Cas Number:
78-40-0
Molecular formula:
C6H15O4P
IUPAC Name:
triethyl phosphate
Details on test material:
no data
Radiolabelling:
yes
Remarks:
32P labeled compound were used

Test animals

Species:
other: not applicable - in vitro method was used
Strain:
other: not applicable - in vitro method was used

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
no data
No. of animals per group:
not applicable - in vitro method was used
Control animals:
no

Results and discussion

Conversion factor human vs. animal skin:
no data

Any other information on results incl. tables

The average maximum steady-state rate of penetration through isolated human skin is 0.623 x 10² µmol/cm² per min.

Applicant's summary and conclusion

Executive summary:

The skin penetranting capacities of a series of organic phosphates were measured by using a skin model in which isolated anterior forearm stratum corneum conjunctum was used.

The average maximum steady-state rate for triethyl phosphate of penetration through isolated human skin is 0.623 x 10² µmol/cm² per min.