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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: artificial skin model - validity for human skin not evident

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Chemical structure and skin penetrating capacity of a short series of organic phosphates and phosphoric acid
Author:
Marzulli F, Callahan JF, Brown DWC
Year:
1965
Bibliographic source:
J Invest Derm, 44, 339-344
Reference Type:
publication
Title:
Die Durchlaessigkeit der Haut fuer ausgewaehlte aliphatische und alicyclische Traegersubstanzen
Author:
Meyer F, Meyer E, Kerk L
Year:
1959
Bibliographic source:
Arzneim Forsch 9, 430-432 (1959) cited in BUA report no 37
Reference Type:
review article or handbook
Title:
Triethylphosphat BUA Stoffbericht 37 (Maerz 1989)
Year:
1989
Bibliographic source:
Beratergremium für umweltrelevante Altstoffe (BUA) d. Ges. Dt. Chemiker, Weinheim, Basel (Schweiz), Cambridge, New York, NY: VCH 1989 (Bua Stoffbericht 37)

Materials and methods

Principles of method if other than guideline:
The skin penetrating capacities of a series of organic phosphates were measured by using a skin model in which isolated anterior forearm stratum corneum conjunctum was used
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data
Radiolabelling:
yes
Remarks:
32P labeled compound were used

Test animals

Species:
other: not applicable - in vitro method was used
Strain:
other: not applicable - in vitro method was used

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
no data
No. of animals per group:
not applicable - in vitro method was used
Control animals:
no

Results and discussion

Conversion factor human vs. animal skin:
no data

Any other information on results incl. tables

The average maximum steady-state rate of penetration through isolated human skin is 0.623 x 10² µmol/cm² per min.

Applicant's summary and conclusion

Executive summary:

The skin penetranting capacities of a series of organic phosphates were measured by using a skin model in which isolated anterior forearm stratum corneum conjunctum was used.

The average maximum steady-state rate for triethyl phosphate of penetration through isolated human skin is 0.623 x 10² µmol/cm² per min.