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Description of key information

The toxicokinetics of triethyl phosphate and metabolism was studied in rats and mice after oral and i.p. application. The skin penetrating capacities of a series of organic phosphates were measured by using a skin model in which isolated anterior forearm stratum corneum conjunctum was used.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

Triethyl phosphate is well absorbed in the gastrointerstinal tract. A dermal absorption in vivo seems possible as indicated in the in vivo and in vitro experiments, the inhalative absorption is less important.

Within 16 hours in rats and mice 90% of the oral or ip applied dose was excreted via urine and nearly 100% of the oral or ip applied dose were excreted within 96 hours via urine. Urine of rats and mice were examined for metabolites of 32P-triethylphosphate. 32P-triethylposphate was excreted by both species as 32-diethylphosphate. As a further metabolite S-ethylcysteine was found. In neither case the trialkyl-phosphate was excreted unchanged. The average maximum steady-state rate for triethyl phosphate of penetration through isolated human skin is 0.623 x 10² µmol/cm² per min.