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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: insufficient documented

Data source

Reference
Reference Type:
publication
Title:
The pharmacologic action of some alcoholic phosphoric esters
Author:
Smith MI
Year:
1936
Bibliographic source:
National Institute of Health bulletin, vol. 165, 11-29 (1936)

Materials and methods

Principles of method if other than guideline:
Triethyl phosphate was examined in albino rats of about 100 to 150 grams. The intraperitoneal route of injection was used.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
950 mg/kg bw

Any other information on results incl. tables

Systemic effects: incoordination, muscular weakness, respiratory and and circulatory paralysis and death in a few minutes

Applicant's summary and conclusion

Executive summary:

LD50 (rat) = 950 mg/kg bw.

Systemic effects: incoordination, muscular weakness, respiratory and and circulatory paralysis and death in a few minutes