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EC number: 201-114-5
CAS number: 78-40-0
In Guideline conform repeated dose studies with 28 and 90 days of oral
treatment NOAELs between 200 and 1000 mg/kg bw/day were determined for
rats. Two not assignable acute oral toxicity studies revealed an LD50 of
1600 mg/kg bw for rat, mouse, and guinea pig and an LD50 of 800 mg/kg bw
for the rat. For mice LD50s of 1500 and 1370 mg/kg bw were reported. A
not assignable acute dermal toxicity study stated an LD50 of > 20.000
mg/kg bw. The key-study for acute inhalation toxicity determined a LC50
> 8817 mg/m³.
The signs observed with this material are those of anesthesia in the
larger doseages. The animals either die promptly from deep anesthesia or
recover completely by the next day. In smaller dosages minimal or no
signs are observed
LD50(rat, mouse, guinea pig) = 1600 mg/kg bw.
Akute inhalation toxicity-aerosol
LC50: > 8817 mg/m³ air
* = No.of mortalities/ No.of animals with symptoms/ No.of animals used
In an acute inhalation toxicity study in rats performed according to
OECD 403 triethyl phosphate showed no acute inhalation toxicity.
Clinical signs observed in the 3360 mg/m³ air group were: untended fur,
diminuated motility, miosis, bloody snout and in the 8817 mg/m³ air
group: untended fur, piloerection, diminuated motility ,ataxia, miosis,
diminuated breathing, accelerated breathing.
Marginal retardation in weight gain in male rats in the first week could
be remarked at 3360 mg/m³ and 8817 mg/m³ air.
The LC50 was > 8817 mg/m³ air.
The NOEL was 1400 mg/m³ 4h air.
From the oral repeated dose studies (overall NOAEL = 200 mg/kg bw) and a
weight of evidence consideration (LD50 = 1600 mg/kg bw, LD50 = 800 mg/kg
bw) for rats and the not assignable studies in mice an overall LD50 >
1000 mg/kg bw seems justified.
Acute inhalation LD50 > 8817 mg/m³ was reported in a guideline study
without restrictions. There are no reliable acute dermal toxicity
studies available. In a study in rabbits a dermal LD 50 > 20000 mg/kg bw
was determined as reported in a peer-reviewed report.
Justification for selection of acute toxicity – oral endpoint
Several oral studies are available. The determined LD50 values were
all in the range > 800 mg/kg bw and ca. 1600 mg/kg bw. In rats mice and
guinea pigs a LD50 of ca. 1600 mg/kg bw was determined. By a weight-of
evidence conideration the data by Deichmann seems most reliable and the
LD50 values from this publication were selected as effect level.
Justification for selection of acute toxicity – inhalation endpoint
The most reliable study was used as key study and for classification.
Based on a weight-of-evidence evaluation of acute and repeated dose
studies a LD50 of > 1000 mg/kg bw is justified. Therefore a
classification with Acute Tox 4 (H302: Harmful if swallowed) is
warranted. This classification is supported by a weight-of-evidence
consideration of the available not assignable studies.
A classification for acute dermal and acute inhalation toxicity is not
justified from the availabe data.
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