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EC number: 201-114-5
CAS number: 78-40-0
Abnormal clinical signs in the high-exposure group included lethargy,
decreased aural response, unsteady gait, and porphyrin nasal discharges
which resolved prior to subsequent exposures. No abnormal clinical signs
were seen in the low-dose group. Weight gain, hematology, clinical
chemistry, and gross and histopathology were unremarkable at both dose
levels. Slightly increased (17 -19%) absolute and relative (to body
weight) liver weights were noted in the high-exposure group, but these
were not considered toxicologically significant in the absence of
histopathology or clinical chemistry changes.
Three groups of 5 male rats were exposed by inhalation to aerosol
concentrations of 0, 366, or 1786 mg/m³ of the test substance 5 h/day, 5
days/week for a total of 12 exposures. About 35% of the test atmosphere
A NOAEL = 366 mg/m³ was observed.
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