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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: insufficient documented

Data source

Reference
Reference Type:
publication
Title:
The metabolism of tri-alkyl phosphates
Author:
Jones AR
Year:
1970
Bibliographic source:
Experimentia 26, 492

Materials and methods

Objective of study:
metabolism
Principles of method if other than guideline:
urine of rats and mice were examined for metabolites of 32P-triethylphosphate
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no further data
Radiolabelling:
yes
Remarks:
32P-triethylphosphate

Test animals

Species:
other: rats and mice
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: oral or intraperitoneal administration
Vehicle:
not specified
Duration and frequency of treatment / exposure:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
ca. 100 mg/kg bw (oral) or 1000 mg/kg bw (intraperitoneal)
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Preliminary studies:
no data

Toxicokinetic / pharmacokinetic studies

Details on absorption:
no data
Details on distribution in tissues:
no data
Details on excretion:
32P-TEP is rapidly excreted as their metabolites by both rat and mouse with 90% recovery of radioactive material in urine within 16 h and nearly complete recovery over 96 h

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
32P-triethylposphate was excreted by both species as 32-diethylphosphate. As a further metabolite S-ethylcysteine was found.

Any other information on results incl. tables

The loss of the alkyl group in trialkyl phosphates is due both to enzymic hydrolysis (P-O cleavage) and de-O-alkylation (C-O cleavage), the latter being known to involve reduced gluthatione as acceptor.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
Executive summary:

32P-TEP is rapidly excreted as their metabolites by both rat and mouse with 90% recovery of radioactive material in urine within 16 h and nearly complete recovery over 96 h. Urine of rats and mice were examined for metabolites of 32P-triethylphosphate. 32P-triethylposphate was excreted by both species as 32-diethylphosphate. As a further metabolite S-ethylcysteine was found. In neither case was the trialkyl-phosphate excreted unchanged.