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EC number: 201-114-5
CAS number: 78-40-0
In the chicken, a sensitive species for delayed neurotoxicity, triethylphosphate gave no indication of neurotoxicity. After single administration of high doses (rat, mouse, i.p. >= 300 mg/kg; dog oral 250 mg/kg) TEP causes narcosis and a cholinesterase inhibition which is slight compared to other phosphoric esters. Cholineesterase inhibition is detectable in in vitro studies.
Following acute symptoms were observed: apathy, staggering gait,
decreased motility, dazed condition, poor reflexes, labored breathing,
diarrhea, red-brown colored feces and ruffled feathers
In 2 surviving animals of the NTE Experiment a slight reduction of body
weight could be observed.
No gross pathology findings in NTE experimental animals that survived
Inhibition in brain- , spinal cord- and spare nerv-homogenates after
single dose application of TEP, respectively vehicle:
a = nmol Phenyl valerat/min*g tissue
b = Media of individual inhibition
Activity of Cholinesterase and inhibition in brain and blood plasma
of hens after single oral application of TEP, respectively vehicle:
a = U7g Tissue
b = media of control values for calculation of ChE-inhibition
c = Value before treatment
d = Value to high (reason not detectable
e = kU/l
NTE analysis results:
In order to detect a possible potential of a delayed neurotoxicity of
TEP, an exploratory study of the effect on NTE (Neuropathy Target
Esterase) in adult hens was executed. TEP was administered in a single
oral (gavage) dose of 2000 mg/kg bw. This dose is in accordance with the
oral LD50 of approximate 2000 mg/kg bw which was tested before (1000
mg/kg bw; 2000 mg/kg bw; 5 animals /dose; 2 animals died in the 2000
mg/kg bw group). in the TEP group following acute symptoms were
observed: apathy, staggering gait, decreased motility, dazed condition,
poor reflexes, labored breathing, diarrhea, red-brown colored feces and
ruffled feathers. In 2 surviving animals (2/6) of the NTE experiment a
slight reduction of body weight could be observed. No gross pathology
findings in NTE experimental animals that survived could be observed. No
relevant decrease of cholinesterase activity in brain (7%) and blood
plasma (0%) were observed. Slight decrease of NTE; no evidence of
delayed neurotoxicity ( brain 31%; spinal cord 43%; spinal nerve 47%;
the effects observed were under the threshold of 80 % which is defined
as the lower limit).
Triethyl phosphate gave no indication of neurotoxicity in chicken
Based on the available data a classification is not justified
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