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Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: insufficient documented

Data source

Reference
Reference Type:
publication
Title:
Short-term intraperitoneal toxicity tests
Author:
Fassett DW, Roundabush RL
Year:
1952
Bibliographic source:
Arch Ind Hyg Occup Med 6, 525-529 (1952)

Materials and methods

Principles of method if other than guideline:
Triethyl phosphate was injected intraperitoneally in rats of 80 to 100 g body weight 5 days a week for four to six weeks. Ten or 20% concentrations were often used.. Dosage was 400 mg/kg bw (ca. half of LD50).
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: intraperitoneal application
Vehicle:
propylene glycol
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
4 to 6 weeks
Frequency of treatment:
daily (5 days per week)
Doses / concentrations
Remarks:
Doses / Concentrations:
400 mg/kg bw
No. of animals per sex per dose:
no data
Control animals:
yes, concurrent vehicle

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

No influence on body weight gain was observed. No hemorrhagic tendency of triethyl phosphate.

Applicant's summary and conclusion

Executive summary:

Triethyl phosphate was injected intraperitoneally in rats of 80 to 100 g body weight 5 days a week for four to six weeks. Ten or 20% concentrations were often used.. Dosage was 400 mg/kg bw (ca. half of LD50). The body weight gain was determined. No mortality was reported. No influence on body weight gain was observed. No hemorrhagic tendency of triethyl phosphate.