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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1991

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Controls:
yes
Amount / concentration applied:
100 µl
Duration of treatment / exposure:
24 h
Observation period (in vivo):
21 d
Number of animals or in vitro replicates:
3, female

Results and discussion

In vivo

Results
Remarks on result:
other: see: Remarks on results
Other effects:
see: remarks on results

Any other information on results incl. tables

Test for irritant effect on the eye (expos.24 h)

 Animal No: (body weight)  tissue  signs  DRAIZE grades                    Irrit. index
       1h  24h  48h  72h  7d  14d  21d  
 D38, female (3,8 kg)  cornea  o  1  2  2  1  0  0  0  1,7
     a  4  4  4  4  0  0  
  fluorescein  i  -  1  2  1  0  -  -  
     a  -  4c  3c  2c  0  -  -  
   iris    0  0  0  0  0  0  0  0,0
  conjunctivae  r  0  2  2  2  0  0  0  2,0
     s  3  2  0  0  0  0  0  0,7
  aqueoushumour  0  0  0  0  0  0  0  0  
   discharge  3  3  2  2  0  0  0  0  
 F21, female(3,7 kg)  cornea  o  1  2  2  1  0  0  0  1,7
     a  4  4  4  4  0  0  0  
   fluorescein  i  -  1  1  1  0  -  -  
     a  -  4c  3c  1c  0  -  -  
   iris    0  0  0  0  0  0  0  0,0
   conjunctivae  r  0  2  2  2  0  0  0  2,0
     s  4  2  0  0  0  0  1,7
   aqueous humour    0  0  0  0  0  0  0  
   discharge    3  3  1  1  0  0  0  
 D33, female(3,6 kg)  cornea  o  1  2  2  1  1  1  0  1,7
     a  4  4  4  4  3  0  
   fluorescein  i  -  1  2  1  1  0  0  
     a  -  3c  4c  4c 1c   0  0  
   iris    0  0  0  0  0  0  0  0,0
   conjunctivae  r  0  2  2  2  0  0  0  2,0
     s  3  0  0  0  0  0  0  0,0
   aqueous humour    0  0  0  0  0  0  0  
   discharge    3  3  1  1  0  0  0  

o = opacity

a = area

i = intensity

r = redness

s = swelling

- = not examined

c = confluent diffuse areas

Applicant's summary and conclusion

Interpretation of results:
moderately irritating
Remarks:
Migrated information
Executive summary:

The irritant effects of the test substance TEP were tested in an eye irritation study in rabbits in accordance with the OECD Guideline No. 405.

The substance was moderately irritating to the eye (exposure period: 24 hrs) with a mean conjuctivae score of 2.0.