Registration Dossier
Registration Dossier
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EC number: 201-114-5 | CAS number: 78-40-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The in-vitro key-studies (Ames test, HPRT assay, UDS assay) and the in-vivo studies on the mouse (cytogenetics in the bone marrow, dominant lethal assay) were negative.
Other not assignable assays showed a weak positive or positive result. Due to unusual test systems, and/or insufficient documentation these result are regarded as invalid.
Short description of key information:
Aside from several Ames tests with negative results, triethylphosphate induces gene mutations without metabolic activation in S. typhimurium his C117, some bacteria, viruses and a yeast strain. For clarification of the endpoint gene mutation a HPRT test in V79 cell cultures was done. This test revealed a negative result with and without metabolic activation (Brendler-Schwaab, 1996)
In an in vitro UDS test on rat hepatocytes triethylphosphate showed no DNA-damaging effect (Brendler, , 1992). The results for Drosophilia melanogaster in the limited documented recessive-lethal tests are contradictory, while in vivo studies on the mouse (cytogenetics in the bone marrow, dominant lethal test) were negative.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The in-vitro key-studies (Ames test, HPRT assay, UDS assay) and the in-vivo studies on the mouse (cytogenetics in the bone marrow, dominant lethal assay) were negative.
Therefore a classification is not justified
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