Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

The in-vitro key-studies (Ames test, HPRT assay, UDS assay) and the in-vivo studies on the mouse (cytogenetics in the bone marrow, dominant lethal assay) were negative.

Other not assignable assays showed a weak positive or positive result. Due to unusual test systems, and/or insufficient documentation these result are regarded as invalid.


Short description of key information:
Aside from several Ames tests with negative results, triethylphosphate induces gene mutations without metabolic activation in S. typhimurium his C117, some bacteria, viruses and a yeast strain. For clarification of the endpoint gene mutation a HPRT test in V79 cell cultures was done. This test revealed a negative result with and without metabolic activation (Brendler-Schwaab, 1996)
In an in vitro UDS test on rat hepatocytes triethylphosphate showed no DNA-damaging effect (Brendler, , 1992). The results for Drosophilia melanogaster in the limited documented recessive-lethal tests are contradictory, while in vivo studies on the mouse (cytogenetics in the bone marrow, dominant lethal test) were negative.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

The in-vitro key-studies (Ames test, HPRT assay, UDS assay) and the in-vivo studies on the mouse (cytogenetics in the bone marrow, dominant lethal assay) were negative.

Therefore a classification is not justified