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EC number: 214-604-9
CAS number: 1163-19-5
The worker inhalation DNEL long-term exposure, systemic effects, was
calculated to be 6 mg/m3. This is consistent with the acceptable
workplace exposure limit of 5 mg/M3 established by the American Council
of Governmental Hygenists.
The general public inhalation DNEL long-term systemic exposure was
calculated to be 70 mg/m3, while the oral DNEL for long-term systemic
exposure was calculated to be 20 mg/kg bw/d. These DNELs compare
favorably to the U.S. ATSDR intermediate-duration reference dose for the
general population of 10 mg/kg bw/d, the U.S. National Research
Council's lifetime oral RfD of 4 mg/kg/d, and the oral RfD of 4 mg/kg/d
developed by Hardy et al. (2009) using bench mark dose modeling. While
the U.S. Intgrated Risk Information System (IRIS) published an RfD of
0.007 mg/kg/d in 2008, this RfD was improperly based on Viberg et al.
(2003), which is not reliable and disregarded in this assessment. To
investigate the effects reported by Viberg et al. after a single dose of
20 mg/kg, a robust, guideline- and GLP-compliant developmental
neurotoxicity study was performed, which demonstrated a NOAEL of 1000
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