Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study performed prior to international guidelines and GLPs

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Toxicological and environmental factors involved in the selection of decabromodiphenyl oxide as a fire retardant chemica
Author:
Norris et al
Year:
1974
Bibliographic source:
JFF/Combustion Toxicology 1, 52-77.
Reference Type:
publication
Title:
Toxicological and environmental factors involved in the selection of decabromodiphenyl oxide as a fire retardant chemical,
Author:
Norris et al.
Year:
1973
Bibliographic source:
Applied Polymer Symposia. No.22. Polymeric Materials for Unusual Service Conditions. 195-219.
Reference Type:
publication
Title:
Toxicology and human health assessment of decabromodiphenyl ether
Author:
Hardy et al.
Year:
2009
Bibliographic source:
Critical Reviews in Toxicology 39(S3): 1-44.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
see below
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Former commercial product FR BA-300 used. Composed of 77% BDE 209, 22% nonaBDEs and 0.8% octaBDEs.

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
occlusive
Preparation of test site:
other: shaved, with or with abrasion
Vehicle:
unchanged (no vehicle)
Controls:
no
Duration of treatment / exposure:
see below
Observation period:
see below
Number of animals:
see below

Results and discussion

Any other information on results incl. tables

see below

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Not irritating.
Executive summary:

Norris et al. (1973, 1974) reported that FR-300-BA applied as dry solid on shaved skin of New Zealand albino rabbits caused essentially no response on intact skin and a slight erythematous and edematous response on abraded skin after a single exposure of 24 h. Repeated exposures to intact skin for 5 days/week for 2 weeks and to abraded skin for 3 days did not alter the responses observed following a single administration.