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EC number: 214-604-9
CAS number: 1163-19-5
The acute toxicity of DecaBDE (purity not stated) was evaluated in New
Zealand white rabbits using groups of 6 (3 males and 3 females) with
dose levels of 0.5, 2.0, 5.0, and 8.0 g/kg. The limit dose was the
highest possible due to mechanical and physical limitations. A single
dose was applied to the clipped backs, under occlusion to an area over
10% of the body surface. Prior to application of the test article, the
skin was abraded on 2 males and 1 female rabbit. The test article was
applied to intact skin on the remainder of the animals. After 24 h, the
occlusion was removed and the test article cleared from the skin.
Animals were monitored for signs of pharmacologic activity and drug
toxicity at 1, 3, 6, and 24 h post dosage, and daily for the remainder
of the 14-day observation period. No test article related toxicity was
observed. Though designed as a LD50 11 experiment, DecaBDE’s physical
and chemical properties preclude it from being a hazard via the dermal
route of exposure.
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