Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study was performed prior to international guidelines and GLPs.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1974
Reference Type:
publication
Title:
Toxicology and human health assessment of decabromodiphenyl ether
Author:
Hardy et al.
Year:
2009
Bibliographic source:
Critical Reviews in Toxicology 39(S3):1-44

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Test conducted prior to international guidelines. However, performance was consistent with today's guidelines.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
other: Spartan
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
not specified
Vehicle:
air
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
1 h
Concentrations:
see below
No. of animals per sex per dose:
see below
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 48.2 mg/L air (nominal)
Based on:
test mat.
Exp. duration:
1 h

Any other information on results incl. tables

see below

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Groups of 5 male and 5 female Spartan rats were exposed for 1 h to 2 or 48.2 mg/L of a commercial DecaBDE product (DE-83) particles in air and subsequently observed for 14 days. All rats survived. Dyspnea and ocular discharge were noted from 2 mg/L concentration (1 animal); moreover, in the 48.2 mg/L group, eye squint and increasing motor activity were observed. All rats were normal at the end of 14-day observation period. Necropsies were not performed.
Executive summary:

Groups of 5 male and 5 female Spartan rats were exposed for 1 h to 2 or 48.2 mg/L of a commercial DecaBDE product (DE-83) particles in air and subsequently observed for 14 days. All rats survived. Dyspnea and ocular discharge were noted from 2 mg/L concentration (1 animal); moreover, in the 48.2 mg/L group, eye squint and increasing motor activity were observed. All rats were normal at the end of 14-day observation period. Necropsies were not performed.