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EC number: 214-604-9
CAS number: 1163-19-5
The in vitro dermal absorption of two flame retardant chemicals,
[14C]decabromodiphenyl oxide (DBDPO) and
[14C]tris-(1,3-dichloro-2-propyl)phosphate (TDCP) were studied. Skin
from the adult hairless female mouse (SKH1) was removed and mounted in
flow-through diffusion cells. The chemicals, at three dose levels
(DBDPO: 6, 30 and 60 nmol; TDCP: 20, 100 and 200 pmol), were applied in
a volatile vehicle (tetrahydrofuran for DBDPO; acetone for TDCP) to the
skin. Fractions of receptor fluid, pumped below the skin, were collected
over a 24-h period. The skin was washed with solvent (tetrahydrofuran
for DBDPO; ethanol for TDCP) to remove unabsorbed chemical 24 h after
application. The receptor fluid, skin wash and skin were analyzed for
chemical-derived radioactivity. The skin from the high-dose group of
both chemicals, and the receptor fluid from TDCP high-dose samples, were
analyzed for parent compound and metabolites by HPLC. The 24-h
cumulative percent of the dose of DBDPO in the receptor fluid was very
low (0.07–0.34%). The applied dose of DBDPO detected in the skin ranged
from 2 to 20%. The lowest dose of DBDPO had the highest percentage of
the dose (20%) in the skin. The major portion of the applied dose was
removed by washing the skin 24 h after application of DBDPO, and ranged
from 77 to 92%. HPLC analysis of homogenate extract prepared from the
high-dose of DBDPO-treated skin showed the presence of DBDPO and a minor
unknown peak. TDCP was readily detected in the receptor fluid; 39–57% of
the applied dose of TDCP was in the receptor fluid by 24 h. The solvent
wash removed 11–25% of the dose from the skin and 28–35% remained in it.
HPLC analysis of the skin homogenate extract and receptor fluid extract
from the TDCP high-dose treated samples showed the presence of parent
compound and a minor unknown peak. TDCP more readily penetrated hairless
mouse skin and diffused into the receptor fluid than DBDPO. TDCP has a
lower molecular weight and log octanol:water partition coefficent than
DBDPO. The differences in the physico-chemical properties of these two
chemicals most likely explains their dissimilar absorption through
hairless mouse skin.
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