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EC number: 214-604-9
CAS number: 1163-19-5
The comercial DecaBDE product did not induce
maternal or fetal toxicity at doses up to 1000 mg/kg/d in rats
administered the material in corn oil from GD0 -19 (NOEL = 1000 mg/kg
bw/d). The commercial DecaBDE product did not induce developmental
neurotoxicity in rats exposed in utero and via lactation through
post-natal day 21 (NOAEL = 1000 mg/kg bw/d). No effects on the
reproductive system were observed in male or female rats and mice when
the commercial DecaBDE product was administered for a lifetime (e.g. two
years) at doses up to 5% of the diet. Similarly, no effects on the
reproductive system were observed in male or female rats and mice at
doses up to 5% of the diet for 90 d. A one-generation reproduction study
in rats using the former commercial product FR 300BA (~77% BDE 209, ~22%
NonaBDEs and 0.8% OctaBDEs) indicated no effects on fertility at doses
up to 100 mg/kg bw/d administered in the diet prior to and during
mating, gestation, and development.
Prenatal developmental and developmental neurotoxicity studies.
The rat oral NOEL from a guideline- and GLP
compliant prenatal developmental study was 1000 mg/kg bw/d, the highest
dose tested, administered from gestation day 0 - 19. The rat oral NOAEL
from a guideline- and GLP-compliant developmental neurotoxicity study
was 1000 mg/kg bw/d administered to maternal animals from gestation day
6 through lactation day 21. See Hardy et al. 2009 (Critical Reviews in
Toxicology 39(S2):1 -44) additional discussion.
DecaBDE is not a reproductive or
developmental toxicant at doses up to, and exceeding, 1000 mg/kg bw/d.
See Hardy et al. (Critical Reviews in Toxicology 39 (S3):1 -44) for a
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