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EC number: 214-604-9
CAS number: 1163-19-5
The comercial DecaBDE product did not induce
maternal or fetal toxicity at doses up to 1000 mg/kg/d in rats
administered the material in corn oil from GD0 -19 (NOEL = 1000 mg/kg
bw/d). The commercial DecaBDE product did not induce developmental
neurotoxicity in rats exposed in utero and via lactation through
post-natal day 21 (NOAEL = 1000 mg/kg bw/d). No effects on the
reproductive system were observed in male or female rats and mice when
the commercial DecaBDE product was administered for a lifetime (e.g. two
years) at doses up to 5% of the diet. Similarly, no effects on the
reproductive system were observed in male or female rats and mice at
doses up to 5% of the diet for 90 d. A one-generation reproduction study
in rats using the former commercial product FR 300BA (~77% BDE 209, ~22%
NonaBDEs and 0.8% OctaBDEs) indicated no effects on fertility at doses
up to 100 mg/kg bw/d administered in the diet prior to and during
mating, gestation, and development.
Prenatal developmental and developmental neurotoxicity studies.
The rat oral NOEL from a guideline- and GLP
compliant prenatal developmental study was 1000 mg/kg bw/d, the highest
dose tested, administered from gestation day 0 - 19. The rat oral NOAEL
from a guideline- and GLP-compliant developmental neurotoxicity study
was 1000 mg/kg bw/d administered to maternal animals from gestation day
6 through lactation day 21. See Hardy et al. 2009 (Critical Reviews in
Toxicology 39(S2):1 -44) additional discussion.
DecaBDE is not a reproductive or
developmental toxicant at doses up to, and exceeding, 1000 mg/kg bw/d.
See Hardy et al. (Critical Reviews in Toxicology 39 (S3):1 -44) for a
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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