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EC number: 214-604-9
CAS number: 1163-19-5
TA98, 100, 1535, 1537; reverse mutation
Wagner and Kling (1998) (a)
WP2 uvrA; reverse mutation
Wagner and Kling (1998)
Mammalian cellsin vitro
Mouse lymphoma cells
L5178Ytk+/tk-; forward mutation
McGregor et al. (1988)
Chinese hamster ovary cells
Mammalian cellsin vivo
Sprague Dawley rats
Cytogenetic evaluation of bone marrow
Norris et al. (1975)
in compliance with the US Food and Drug Administration’sGood
Laboratory Practice for Nonclinical Laboratory Studies(FDA, 2002),
the US EPA’sGood Laboratory Practice Standards(EPA, 1989,
1996), the United Kingdom’sGLP Compliance Programme, the
Japanese GLP Standards, and the OECD’sPrinciples on Good
Laboratory Practice(OECD, 1998).
ND = not determined.
No evidence of a genotoxic effect was detected in the Ames Salmonella,
chromosome aberration, mouse lymphoma, or sister-chromatid exchange
tests (McGregor et al., 1988; NTP, 1986; Wagner & Klug, 1998). No
cytogenic changes were observed in the bone marrow of rats (parents and
offspring) undergoing a one-generation reproduction test using FR-300-BA
(Norris et al., 1975)
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