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EC number: 214-604-9
CAS number: 1163-19-5
In 50 human subjects, repeated application of a suspension of a 5%
commercial product (purity not stated) in petrolatum 3 times a week for
3 weeks and challenged 2 weeks subsequent to the last induction
application did not result in skin sensitisation (Norris et al., 1974,
Additionally, human volunteers (80 males and 120 females) were treated
with 9 induction patches using 2 batches of a commercial product. The
first sample was evaluated as received, and the second as a 2% (w/v)
aqueous suspension. The patches were applied once every Monday,
Wednesday, and Thursday, allowed to contact the skin for 24 h, and the
skin was graded for irritation. Fifteen
subjects among the 200 volunteers showed some slight irritation
reactions: very slight erythema (barely perceptible) in 14/1800 patches,
mild (well-defined) erythema in 2/1800 patches, and very slight edema
(barely perceptible) in 1/1800 patches. After a nonpatching period of 12
days, the challenge patch was applied to detect sensitization. No evidence
of skin sensitisation with either of the test materials in any of the
subjects tested was observed (IBTL, 1975).
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