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EC number: 214-604-9
CAS number: 1163-19-5
To evaluate developmental exposures to commercial DecaBDE products
(97.34% BDE-209, 2.66% nona- and octaBDE congeners), Hardy et al. (2002)
conducted a guideline compliant developmental toxicity study performed
in accordance with good laboratory practice (GLP) standards. In this
study, female Sprague-Dawley rats (25 mated females/group) received 0,
100, 300, or 1000 mg /kg-day via gavage in corn oil on gestation days
0–19. All dams survived until scheduled sacrifice. No clinical signs of
toxicity were observed. Pregnancy rates in the control and treated
groups ranged from 96% to 100% and provided 23 or more litters in each
group for evaluation on gestation day 20. No effect of treatment was
detected in maternal gestational parameters (body
weight, body weight gain, and food consumption), uterine implantation
data, liver weight, or necropsy findings.
Likewise, no treatment-related effects were detected in fetal body
weights, fetal sex distribution, or from the fetal
external, visceral, or skeletal examinations. The no-observed-effect
level (NOEL) for maternal and developmental
toxicity was 1000 mg/kg-day, the highest dose level tested (Hardy, 2002).
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