Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report Date:
1979

Materials and methods

Principles of method if other than guideline:
Two white rabbits (New Zealand) were trated with 0.1 ml nitrobenzene. The test substance was not removed. Observation period was 7 days.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): nitrobenzene
- Analytical purity: no data

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL
Duration of treatment / exposure:
The test substamce remained in the conjunctival sac.
Observation period (in vivo):
24h, 48h, 72h and 7 days
Number of animals or in vitro replicates:
2

Results and discussion

In vivo

Results
Irritation parameter:
other: eye irritation
Basis:
animal #2
Remarks:
rabit
Time point:
other: 7 days
Score:
0

Any other information on results incl. tables

No reaction was observed.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information