Registration Dossier
Registration Dossier
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EC number: 202-716-0 | CAS number: 98-95-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, sufficiently documented and acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
- Principles of method if other than guideline:
- According to: Smyth et al.: Am. Ind. Hyg. Ass. J. 23: 95-107 (1962). Volatile part of compound is directed via airstream (200L/h) into inhalation chamber with a single rat. 12 rats exposed. Exposure times: 3 and 7 hours. The time is determined at which all animals survive. Monitoring time after exposition is 14 days
- GLP compliance:
- no
- Test type:
- other: Inhalation risk test
- Limit test:
- no
Test material
- Reference substance name:
- Nitrobenzene
- EC Number:
- 202-716-0
- EC Name:
- Nitrobenzene
- Cas Number:
- 98-95-3
- Molecular formula:
- C6H5NO2
- IUPAC Name:
- nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): nitrobenzene
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: air
- Analytical verification of test atmosphere concentrations:
- not specified
- Remarks on duration:
- 3 and 7 hours
- Concentrations:
- mean concentration: 2.27 mg/L (7h) and 2.25 mg/L (3h)
- No. of animals per sex per dose:
- single rat per exposition; 12 rats per exposure time
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 2.25 mg/L air
- Based on:
- other: mean concentration of test material
- Exp. duration:
- 3 h
- Sex:
- male/female
- Dose descriptor:
- other: 3/12 rats died after 7h exposition
- Effect level:
- 2.27 mg/L air
- Based on:
- other: mean concentration of test material
- Exp. duration:
- 7 h
Any other information on results incl. tables
Mortality: 0/12 deaths after 3h exposition. 3/12 rats died after 7h exposition at 20°C. After 7 h exposition, animals were gasping for breath, had severe irritation of mucouse membrane and
cyanosis as well as disturbed equilibrium.Animals that died during the study showed acute dilation and congestion of the heart, organs had discolorations and the lung was inflated and filled with blood.
Applicant's summary and conclusion
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