Registration Dossier

Guidance on Safe Use

Guidance on Safe Use

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Administrative data

First-aid measures

General advice: Remove victims from the danger zone without endangering your own safety.
Remove contaminated or soaked clothing (including underwear and shoes) immediately.
If inhaled: Bring accident victims out into the fresh air. If patient has difficulty in breathing,
administer oxygen, keep the patient calm and warm. Call a physician immediately.
In case of skin contact: After contact with skin, wash immediately with plenty of soap and
water. Apply protective bandage with sterile gauze. Call a physician immediately.
In case of eye contact: Hold the eyes open and rinse with preferably lukewarm water for a
sufficiently long period of time (at least 10 minutes). Contact an ophthalmologist.
If swallowed: If product is swallowed DO NOT induce the patient to vomit, medical advice is
required. Make patient drink water and rinse out mouth several times (only if injured person is
conscious).
Therapeutic measures: Basic first aid, decontamination, symptomatic treatment.

Fire-fighting measures

FIRE FIGHTING MEASURES

Classes of fires :
Liquid or melting substances

Suitable extinguishing media: Carbon dioxide (CO2), Foam, extinguishing powder, in cases of
larger fires, water spray should be used.

Unsuitable extinguishing media: High volume water jet
Burning releases carbon monoxide, carbon dioxide, oxides of nitrogen and traces of hydrogen
cyanide. In the event of fire and/or explosion do not breathe fumes.
During fire-fighting respirator with independent air-supply and airtight garment is required.
Fight fire in early stages if safe to do so. Containers at risk from fire should be cooled with water
and, if possible, removed from the danger area. Do not allow contaminated extinguishing water
to enter the soil, ground-water or surface waters

Instructions :
Cool surrounding containers with water spray.
If possible, take container out of dangerous zone.
Heating causes a rise in pressure, risk of bursting and
explosion.
Shut off sources of ignition.
Stay on upwind side.
Heavy generation of soot.

Special protective equipment :
Attention! Hazardous decomposition products may occur.
Nitrous gases (nitric oxides)
Wear self-contained breathing apparatus.
In case of violent hazardous effect:
Wear a special tightly sealed suit.

Accidental release measures

Evacuate area. Warn affected surroundings.
The hazardous area may only be entered once suitable
protective measures are implemented. Only then can the
hazardous situation be removed.

Personal precautions: Put on protective equipment. Keep away from sources
of ignition. Ensure adequate ventilation/exhaust extraction. Keep unauthorized persons away.

Methods for cleaning up: Take up with absorbent for chemicals or, if necessary with dry sand.
Fill into labeled, sealable containers. Also place used cleaning materials into closable receptacles.

Prevent spread of the liquid.
Absorb any spilt liquid with an absorbent (e.g. diatomite, vermiculite, sand) and dispose of according to regulations.
Attention! Substance reacts with water. Avoid contact with water.
Afterwards ventilate area and wash spill site.

Endangerment of drinking water and environment: Avoid escape into water, drainage, sewer, or the ground.
Environmental precautions: Do not flush into surface water or sanitary sewer system.

A hazard for drinking water sources when larger quantities get into groundwater.
Inform the responsible authorities.
Maybe a hazard to the surrounding atmosphere if larger
quantities of the substance escape. Inform the authorities.

Methods for cleaning up: Take up with absorbent for chemicals or, if necessary with dry sand.
Fill into labeled, sealable containers. Also place used cleaning materials into closable receptacles

Handling and storage

HANDLING

Handling
Handle in closed, grounded apparatus. Ensure proper ventilation and including at floor level.
Make sure all pipelines, tanks and equipment are leakproof.
Organize work procedures so that workers are not exposed to the effects of the products. Vent
waste air only via suitable separators or scrubbers.
Explosion protection required. Precautions should generally be taken against electrostatic
charges according to the equipment used and the way the product is handled and packaged.
The personal protective measures described below must be observed. Contact with skin
and eyes and inhalation of vapors must be avoided under all circumstances.


Workplace:
Provision of very good ventilation in the working area.
Especially at higher temperatures.
The floor must be solvent resistant.
The floor should not have a floor drain.
Washing facility at the workplace required.
Eye bath required. These locations must be signposted
clearly.
When handling excessive amounts of the substance an
emergency shower is required.

Equipment :
Use only closed apparatus.
If release of the substance cannot be prevented, then it
should be suctioned off at the point of exit.
Consider emission limit values, a purification of waste
gases if necessary.
Label containers and pipelines clearly.

Advice on safer handling :
Take care to maintain clean working place.
The substance must not be present at workplaces in
quantities above that required for work to be progressed.
Do not leave container open.
Use leak-proof equipment with exhaust for refilling or
transfer.
Do not transport with/using compressed air at temperatures
above 70 degree C.
Avoid splashing.
Fill only into labelled container.
Use solvent resistant utensils.
Avoid any contact when handling the substance.
Prevent seepage into flooring (use of a steel tub).
Use an appropriate exterior vessel when transporting in
fragile containers.

Cleaning and maintenance :
Use protective equipment while cleaning if necessary.
Do not clean damp.
Only conduct maintenance and other work on or in the vessel
or closed spaces after obtaining written permission.
Only work with vessels and lines after they have been
thoroughly rinsed.


STORAGE:

Storage
Keep container dry and tightly closed in a cool and well ventilated place.
Keep away from strong oxidizing agents.
VCI storage class (VCI = German Association of the Chemical Industry): 3B

Keep in locked storage or only make accessible to
specialists or their authorised assistants.
Do not use any food containers - risk of mistake.
Containers have to be labelled clearly and permanently.
Store in the original container as much as possible.
Place fragile vessels in break-proof outer vessels.
Keep container tightly closed.
Recommended storage at room temperature.
Keep container in a well-ventilated place.
If more than 200 kg of toxic and highly toxic substances
are to be stored, or if the proportion of highly toxic
substances is more than 50 kg, then follow the rules of
TRGS 514.

Transport information

Land transport (ADR/RID)

UN number:
1662
Shippingopen allclose all
Class:
6.1
Classification code:
60
Packaging group:
II
Labels:
6.1
SpecialProvisionsopen allclose all

Inland waterway transport (ADN(R))

UN number:
1662
Shippingopen allclose all
Class:
6.1
Classification code:
60
Packaging group:
II
Labels:
6.1
Remarks
Labels when shipped in tank vessels : 6.1 + N2

Marine transport (IMDG)

UN number:
1662
Proper shipping name and description:
NITROBENZENE
Chemical name:
Nitrobenzene
Class:
6.1
Packaging group:
II
EmS code:
F-AS, S-A
Labels:
6.1
Marine pollutant
Remarks
Limited quantity regulations applicable in accordance with chapter 3.4 RID/ADR/ADN in compliance
with threshold value
Other information : Toxic. Combustible.
Environmentally hazardous substance.
Keep separated from foodstuffs.

Air transport ICAO/IATA

UN number:
1662
Proper shipping name and description:
Nitrobenzene
Chemical name:
Nitrobenzene
Class:
6.1
Packaging group:
II
Labels:
Toxic
Remarks
Packing instruction (cargo aircraft only): 662
Packing instruction (passenger and cargo aircraft): 654
SpecialProvisionsopen allclose all

Exposure controls / personal protection

Body protection:
Depending on the risk, wear a tight, long apron and boots or suitable imprevious chemical protection clothing.
The protection clothing should be solvent resistant.
Wear flameproof, antistatic protective clothing.

Respiratory protection :
If vapors form, respirators must be used. Put on full-mask respirator with filter type ABEK.
At higher concentrations or under uncertain conditions a respirator with independent air supply must be used.

Eye protection :
Sufficient eye protection should be worn.
Wear glasses with side protection. If the eyes may potentially come in contact with the liquids, then chemical safety goggles are necessary.

Hand protection :
Use protective gloves. The glove material must be sufficiently impermeable and resistant to the substance.
Check the tightness before wear. Gloves should be well cleaned before being removed, then stored in a well ventilated location. Pay attention to skin care.
Textile or leather gloves are completely unsuitable.

The following materials are suitable for protective gloves
Conditionally suitable materials for protective gloves; EN 374-3:
(Permeation time >= 8 hours):
Nitrile rubber/Nitrile latex - NBR (>= 0.35 mm) The SDS indicated for the material list that NBR is suitable!
Butyl rubber - Butyl (0,5 mm)
Fluoro carbon rubber - FKM (0,4 mm)
The producer “Ansell” gives an approval to use NBR (Sol-Knit)

Following materials are unsuitable for protective gloves:
Natural rubber/Natural latex - NR
Polychloroprene - CR
Polyvinyl chloride - PVC

The times listed are suggested by measurements taken at 22 degree C and permanent contact. Temperatures raised
by warmed substances, body heat, etc. and a weakening of the effective layer thickness caused by expansion can lead
to a significantly shorter breakthrough time.
In case of doubt contact the gloves' manufacturer.
A 1.5-times increase / decrease in the layer thickness
doubles / halves the breakthrough time. This data only
applies to the pure substance. Transferred to mixtures of substances, these figures should only be taken as an aid to orientation.

Skin protection :
Skin protection preparations do not protect sufficiently against the substance. Wear protective gloves.
Before a break wash hands and face with soap and water, after work take a shower if applicable.
Apply fatty skin-care products after washing.

Industrial hygiene :
If at risk of contamination, foods, tobacco, beverages and other articles of consumption must not be stored or consumed at the work areas.
Special areas are to be designated for these purposes.
Avoid contact with skin. Do not allow the substance or its solution to dry on the skin. In case of contact wash skin.
Avoid contact with eyes. In case of contact rinse the affected eye(s).
Avoid inhalation of vapour/dust.
In NO case, drink alcohol.
Avoid contact with clothing. Contaminated clothes must be exchanged and cleaned carefully.
Before a break it might be necessary to change clothes.
Provide washrooms with showers and rooms with separate storage for street clothing and work clothing if there is a possibility of contamination of work clothes. Take care of personal hygiene.


Stability and reactivity

Building explosive gas mixtures with air
Hazardous reactions: No hazardous reactions when used as directed.
Hazardous decomposition products: No hazardous decomposition products when stored and
handled correctly.
Thermal decomposition: No thermal decomposition when stored and handled correctly.
Materials to avoid: Possibility of dangerous reactions with reducing agents and strong oxidants.

Disposal considerations

Hazardous waste according to Waste Catalogue Ordinance (AVV).
If there is no way of recycling it must be disposed of in compliance with the respective national and local regulations.

Collection of small amounts of substance:
Collect in container for toxic, flammable compounds.
Collection vessels must be clearly labelled with a systematic description of their contents and with the hazard symbol and the R and S phrases. Store the vessels in a well-ventilated location. Entrust them to the appropriate authorities for disposal.

Dispose in accordance with applicable international, national and local laws, ordinances and
statutes. For disposal within the EC, the appropriate code according to the European Waste Catalogue (EWC) should be used.
After containers have been emptied as thoroughly as possible (e.g. by pouring, scraping or
draining until "drip-dry"), they can be sent to an appropriate collection point set up within the
framework of the existing take-back scheme of the chemical industry. Containers must be
recycled in compliance with national legislation and environmental regulations.